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Th17 Cells

CD4+ T helper cells are critical mediators of the cellular immune response. For many years, it was thought that CD4+ T helper cells existed as a dichotomy of lineages identified as Th1 and Th2 based on their expression pattern of effector cytokines. This paradigm was challenged with the demonstration that IL-17 (also known as IL-17A) was produced and secreted as a homodimer or heterodimer (with IL-17F) by a unique subset of T helper cells with the subsequent identification of ROR gamma (t) as the transcription factor responsible for specifying the lineage differentiation of Th17 cells. Th17 cell development is also driven and regulated by the expression of transcription factors STAT3, AHR, BATF, IRF4, c-Maf, IKB zeta and ROR alpha. Th17 cells play a role in host defense against extracellular pathogens and there is significant evidence that aberrant regulation of Th17 cells plays a role in the pathogenesis of multiple inflammatory and autoimmune disorders.

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Name Clone Application Cat. No. Reg.  

Anti-Mouse CD4 Alexa Fluor® 488

GK1.5 FC 53-0041 RUO

Anti-Mouse CD4 Alexa Fluor® 700

GK1.5 FC 56-0041 RUO

Anti-Mouse CD4 APC

GK1.5 FC 17-0041 RUO

Anti-Mouse CD4 APC-eFluor® 780

GK1.5 FC 47-0041 RUO

Anti-Mouse CD4 Biotin

GK1.5 FC 13-0041 RUO

Anti-Mouse CD4 eFluor® 450

GK1.5 FC 48-0041 RUO

Anti-Mouse CD4 eFluor® 660

GK1.5 FC 50-0041 RUO

Anti-Mouse CD4 FITC

GK1.5 FC 11-0041 RUO

Anti-Mouse CD4 Functional Grade Biotin

GK1.5 FC, IHC, IHC-F, IP 36-0041 RUO

Anti-Mouse CD4 Functional Grade Purified

GK1.5 FC, FA 16-0041 RUO

Anti-Mouse CD4 PE

GK1.5 FC 12-0041 RUO

Anti-Mouse CD4 PE-Cyanine5

GK1.5 FC 15-0041 RUO

Anti-Mouse CD4 PE-Cyanine7

GK1.5 FC 25-0041 RUO

Anti-Mouse CD4 PE-eFluor® 610

GK1.5 FC 61-0041 RUO

Anti-Mouse CD4 PerCP-eFluor® 710

GK1.5 FC 46-0041 RUO

Anti-Mouse CD4 Purified

GK1.5 FC, IHC, IHC-F, IP 14-0041 RUO

Anti-Human CD4 Biotin

N1UG0 FC, IHC, IHC-P, WB 13-2444 RUO

Anti-Human CD4 eFluor® 570

N1UG0 IHC, IHC-P 41-2444 RUO

Anti-Human CD4 Purified

N1UG0 IHC, IHC-P, WB 14-2444 RUO

Anti-Human CD4 Alexa Fluor® 488

OKT4 (OKT-4) FC 53-0048 RUO

Anti-Human CD4 Alexa Fluor® 700

OKT4 (OKT-4) FC 56-0048 RUO

Anti-Human CD4 APC

OKT4 (OKT-4) FC 17-0048 RUO

Anti-Human CD4 APC-eFluor® 780

OKT4 (OKT-4) FC 47-0048 RUO

Anti-Human CD4 Biotin

OKT4 (OKT-4) FC 13-0048 RUO

Anti-Human CD4 eFluor® 450

OKT4 (OKT-4) FC 48-0048 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents