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Th17 Cells

CD4+ T helper cells are critical mediators of the cellular immune response. For many years, it was thought that CD4+ T helper cells existed as a dichotomy of lineages identified as Th1 and Th2 based on their expression pattern of effector cytokines. This paradigm was challenged with the demonstration that IL-17 (also known as IL-17A) was produced and secreted as a homodimer or heterodimer (with IL-17F) by a unique subset of T helper cells with the subsequent identification of ROR gamma (t) as the transcription factor responsible for specifying the lineage differentiation of Th17 cells. Th17 cell development is also driven and regulated by the expression of transcription factors STAT3, AHR, BATF, IRF4, c-Maf, IKB zeta and ROR alpha. Th17 cells play a role in host defense against extracellular pathogens and there is significant evidence that aberrant regulation of Th17 cells plays a role in the pathogenesis of multiple inflammatory and autoimmune disorders.

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Name Clone Application Cat. No. Reg.  

Anti-Human CD3 Functional Grade Purified

SK7 FC, FA 16-0036 RUO

CD3 PE

SK7 FC 9012-0036 CE

Anti-Human CD3 PE

SK7 FC 12-0036 RUO

Anti-Human CD3 PE-Cyanine7

SK7 FC 25-0036 RUO

Anti-Human CD3 PE-Cyanine5.5

SK7 FC 35-0036 RUO

CD3 PerCP

SK7 FC 9043-0036 CE

CD3 PerCP

SK7 FC 8043-0036 ASR

Anti-Human CD3 PerCP-Cyanine5.5

SK7 FC 45-0036 RUO

CD3 PerCP-Cyanine5.5

SK7 FC 8045-0036 ASR

CD3 PerCP-Cyanine5.5

SK7 FC 9045-0036 CE

Anti-Human CD3 PerCP-eFluor® 710

SK7 FC 46-0036 RUO

Anti-Human CD3 Alexa Fluor® 532

UCHT1 FC 58-0038 RUO

Anti-Human CD3 Alexa Fluor® 700

UCHT1 FC 56-0038 RUO

Anti-Human CD3 APC

UCHT1 FC 17-0038 RUO

Anti-Human CD3 APC-eFluor® 780

UCHT1 FC 47-0038 RUO

Anti-Human CD3 Biotin

UCHT1 FC 13-0038 RUO

Anti-Human CD3 eFluor® 450

UCHT1 FC 48-0038 RUO

Anti-Human CD3 eFluor® 506

UCHT1 FC 69-0038 RUO

Anti-Human CD3 FITC

UCHT1 FC 11-0038 RUO

Anti-Human CD3 Functional Grade Purified

UCHT1 FC, FA 16-0038 RUO

Anti-Human CD3 PE

UCHT1 FC 12-0038 RUO

Anti-Human CD3 PE-Cyanine5

UCHT1 FC 15-0038 RUO

Anti-Human CD3 PE-Cyanine7

UCHT1 FC 25-0038 RUO

Anti-Human CD3 PE-eFluor® 610

UCHT1 FC 61-0038 RUO

Anti-Human CD3 Purified

UCHT1 FC, IHC, IHC-F, FA 14-0038 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents