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Th17 Cells

CD4+ T helper cells are critical mediators of the cellular immune response. For many years, it was thought that CD4+ T helper cells existed as a dichotomy of lineages identified as Th1 and Th2 based on their expression pattern of effector cytokines. This paradigm was challenged with the demonstration that IL-17 (also known as IL-17A) was produced and secreted as a homodimer or heterodimer (with IL-17F) by a unique subset of T helper cells with the subsequent identification of ROR gamma (t) as the transcription factor responsible for specifying the lineage differentiation of Th17 cells. Th17 cell development is also driven and regulated by the expression of transcription factors STAT3, AHR, BATF, IRF4, c-Maf, IKB zeta and ROR alpha. Th17 cells play a role in host defense against extracellular pathogens and there is significant evidence that aberrant regulation of Th17 cells plays a role in the pathogenesis of multiple inflammatory and autoimmune disorders.

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Name Clone Application Cat. No. Reg.  

Anti-Mouse CD366 (TIM3) Purified

RMT3-23 FC 14-5870 RUO

Anti-Mouse CD366 (TIM3) PE-Cyanine7

RMT3-23 FC 25-5870 RUO

Anti-Mouse CD366 (TIM3) PE

RMT3-23 FC 12-5870 RUO

Anti-Mouse CD366 (TIM3) Purified

8B.2C12 FC, IHC, IP 14-5871 RUO

Anti-Mouse CD366 (TIM3) PE

8B.2C12 FC 12-5871 RUO

Anti-Mouse CD366 (TIM3) Functional Grade Purified

8B.2C12 FC, FA 16-5871 RUO

Anti-Mouse CD366 (TIM3) eFluor® 450

8B.2C12 FC 48-5871 RUO

Anti-Mouse CD366 (TIM3) Biotin

8B.2C12 FC, IHC 13-5871 RUO

Anti-Mouse CD366 (TIM3) APC

8B.2C12 FC 17-5871 RUO

Anti-Human CD366 (TIM3) Functional Grade Purified

F38-2E2 FA 16-3109 RUO

Anti-Human CD366 (TIM3) Super Bright 436

F38-2E2 FC 62-3109 RUO

Anti-Human CD366 (TIM3) PerCP-eFluor® 710

F38-2E2 FC 46-3109 RUO

Anti-Human CD366 (TIM3) PE-Cyanine7

F38-2E2 FC 25-3109 RUO

Anti-Human CD366 (TIM3) PE

F38-2E2 FC 12-3109 RUO

Anti-Human CD366 (TIM3) FITC

F38-2E2 FC 11-3109 RUO

Anti-Human CD366 (TIM3) eFluor® 450

F38-2E2 FC 48-3109 RUO

Anti-Human CD366 (TIM3) APC-eFluor® 780

F38-2E2 FC 47-3109 RUO

Anti-Human CD366 (TIM3) APC

F38-2E2 FC 17-3109 RUO

ProcartaPlex Human TIM-3 (CD366) Simplex

Multiplex EPX01A-12219 RUO

Human TIM-3 Platinum ELISA

ELISA BMS2219* RUO

Mouse Th17 Cytokine Staining Panel

FC 88-8411 RUO

Human Th17 Cytokine Staining Panel

FC 88-8419 RUO

ProcartaPlex Human Th9/Th17/Th22/Treg & Cytokine Panel 1C (14 plex)

Multiplex EPX140-12174 RUO

ProcartaPlex Human Th9/Th17/Th22/Treg & Chemokine Panel 1 (16 plex)

Multiplex EPX160-12175 RUO

ProcartaPlex Mouse Th9/Th17/Th22/Treg & Chemokine Panel (15 plex)

Multiplex EPX150-26089 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents