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Th17 Cells

CD4+ T helper cells are critical mediators of the cellular immune response. For many years, it was thought that CD4+ T helper cells existed as a dichotomy of lineages identified as Th1 and Th2 based on their expression pattern of effector cytokines. This paradigm was challenged with the demonstration that IL-17 (also known as IL-17A) was produced and secreted as a homodimer or heterodimer (with IL-17F) by a unique subset of T helper cells with the subsequent identification of ROR gamma (t) as the transcription factor responsible for specifying the lineage differentiation of Th17 cells. Th17 cell development is also driven and regulated by the expression of transcription factors STAT3, AHR, BATF, IRF4, c-Maf, IKB zeta and ROR alpha. Th17 cells play a role in host defense against extracellular pathogens and there is significant evidence that aberrant regulation of Th17 cells plays a role in the pathogenesis of multiple inflammatory and autoimmune disorders.

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Name Clone Application Cat. No. Reg.  

Anti-Human ACT1 Purified

9ACT12 WB 14-4040 RUO

Anti-Mouse CD3 Alexa Fluor® 532

17A2 FC 58-0032 RUO

Anti-Mouse CD3 Alexa Fluor® 700

17A2 FC 56-0032 RUO

Anti-Mouse CD3 APC-eFluor® 780

17A2 FC 47-0032 RUO

Anti-Mouse CD3 Biotin

17A2 FC 13-0032 RUO

Anti-Mouse CD3 eFluor® 450

17A2 FC 48-0032 RUO

Anti-Mouse CD3 eFluor® 506

17A2 FC 69-0032 RUO

Anti-Mouse CD3 eFluor® 660

17A2 FC, IHC, IHC-F 50-0032 RUO

Anti-Mouse CD3 Functional Grade Purified

17A2 FC, FA 16-0032 RUO

Anti-Mouse CD3 PerCP-eFluor® 710

17A2 FC 46-0032 RUO

Anti-Mouse CD3 Purified

17A2 FC, IHC, IHC-F, FA 14-0032 RUO

Anti-Rat CD3 APC

eBioG4.18 (G4.18) FC 17-0030 RUO

Anti-Rat CD3 Biotin

eBioG4.18 (G4.18) FC, IHC, IHC-F 13-0030 RUO

Anti-Rat CD3 FITC

eBioG4.18 (G4.18) FC 11-0030 RUO

Anti-Rat CD3 Functional Grade Purified

eBioG4.18 (G4.18) FC, IHC, FA 16-0030 RUO

Anti-Rat CD3 PE

eBioG4.18 (G4.18) FC 12-0030 RUO

Anti-Rat CD3 PerCP-eFluor® 710

eBioG4.18 (G4.18) FC 46-0030 RUO

Anti-Rat CD3 Purified

eBioG4.18 (G4.18) FC, IHC, IP, WB 14-0030 RUO

eZFluor™ Anti-Human CD3 FITC and CD4 PE Cocktail

FC 22-0304 RUO

Anti-Human CD3 FITC

HIT3a FC 11-0039 RUO

Anti-Human CD3 Functional Grade Purified

HIT3a FC, FA 16-0039 RUO

Anti-Human CD3 PE

HIT3a FC 12-0039 RUO

Anti-Human CD3 Purified

HIT3a FC 14-0039 RUO

Anti-Human CD3 eFluor® 660

OKT3 FC 50-0037 RUO

Anti-Human CD3 Alexa Fluor® 488

OKT3 FC 53-0037 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents