T Regulatory Cells

T regulatory (Treg) cells are CD4+ T helper cells that are critical to the maintenance of immune cell homeostasis as evidenced by the catastrophic consequences of genetic or physical ablation of the Treg population. Specifically, Treg cells maintain order in the immune system by enforcing a dominant negative regulation on other immune cells. Treg cells manifest their function through a myriad of mechanisms that include the secretion of soluble factors, cell contact mediated regulation, and cytolytic activity. Treg cells are characterized by their expression of the Foxp3 transcription factor that specifies differentiation of the lineage.

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Name Clone Application Cat. No. Reg.  

Anti-Mouse CD3 eFluor® 660

17A2 FC, IHC 50-0032 RUO

Anti-Mouse CD4 eFluor® 660

4SM95 IHC 50-9766 RUO

Anti-Rat CD25 APC

OX39 FC, IHC 17-0390 RUO

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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents