NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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NK Cell Markers

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Name	Clone	Application	Cat. No.	Reg.
Anti-Human/Non-Human Primate CD8b Purified	SIDI8BEE	FC, IP, WB	14-5273	RUO
Anti-Human CD11b (activation epitope) Purified	CBRM1/5	FC, FA, IP	14-0113	RUO
Anti-Human CD26 Purified	M-A261	FC, IHC, IP	BMS143*	RUO
Anti-Human/Mouse CD27 Purified	LG.3A10	FC, IHC, IP	14-0272	RUO
Anti-CD27 Purified	LG.7F9	FC, FA, IP	14-0271	RUO
Anti-Human CD30 Purified	Ki-2	FC, ELISA, IP, WB	BMS1024*	RUO
Anti-Human CD178 (CD95 Ligand) Purified	NOK-1	FC, FA, IP	14-9919	RUO
Anti-Human CD218a (IL-18 Receptor alpha) Purified	H44	FC, IHC, IP, WB	14-7183	RUO
Anti-Human CD244 Purified	eBioPP35 (PP35)	FC, IP, WB	14-2449	RUO
Anti-Human CD277 Purified	eBioBT3.1 (20.1, BT3.1)	FC, IP	14-2779	RUO
Anti-Human CD314 (NKG2D) Purified	1D11	FC, IHC, FA, IP	14-5878	RUO
Anti-Human CD314 (NKG2D) Purified	5C6	FC, IHC, FA, IP	14-5879	RUO
Anti-Human CD328 (Siglec7) Purified	eBioQA79 (QA79)	FC, IP	14-5759	RUO
Anti-human Galectin-3	M3/38	FC, ELISA, IHC, IP, WB	BMS1043*	RUO
Anti-human IFN-gamma	B140	ELISA, IP	BMS1018*	RUO
Anti-human IFN-gamma	B308	ELISA, IP	BMS1019*	RUO
Anti-Human IL-15 Receptor Purified	eBioJM7A4	FC, IP, WB	14-7159	RUO
Anti-Human LAP Functional Grade Purified	VB3A9	IHC, IP, WB	16-9823	RUO
Anti-Human LAT Purified	LAT.10-17 (10-17)	IP, WB	14-9967	RUO
Anti-Human MICA/B Functional Grade Purified	6D4	FC, IHC, FA, IP	16-5788	RUO
Anti-Human MICA/B Purified	6D4	FC, IHC, FA, IP	14-5788	RUO
Anti-Human/Mouse mTOR Purified	F11	IHC, IP, WB	14-2190	RUO
Anti-NF kappa B p50 and p105 Purified	Polyclonal	IHC, IP, WB	14-6732	RUO
Anti-NF kappa B p65 Purified	Polyclonal	IHC, IP, WB	14-6731	RUO
Anti-Human CD31 (PECAM-1) Purified	Gi-34	FC, ELISA, FA, IP, WB	BMS1020*	RUO
Anti-Human Perforin Purified	dG9 (delta G9)	IHC, IP	14-9994	RUO
Anti-Human/Mouse ZAP-70 Purified	1E7.2	FC, IP, WB	14-6695	RUO

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents