NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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NK Cell Markers

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Name	Application	Cat. No.	Reg.
Recombinant Human sAPO-1/Fas		BMS314*	RUO
Mouse CCL3 (MIP-1 alpha) Recombinant Protein	FA	14-8000	RUO
Mouse CCL3 (MIP-1 alpha) Recombinant Protein Carrier-Free	FA	34-8000	RUO
Recombinant Human sCD40 Ligand	FC, ELISA	BMS308/2*	RUO
Human CCL4 (MIP-1 beta) Recombinant Protein	FA	14-8938	RUO
Human CCL4 (MIP-1 beta) Recombinant Protein Carrier-Free	FA	34-8938	RUO
Human CXCL1 (GRO alpha) Recombinant Protein Carrier-Free (To Be Discontinued)	FA	34-8942	RUO
Recombinant Human IFN-gamma	FC, ELISA	BMS303*	RUO
Recombinant Mouse IFN gamma		BMS326*	RUO
Mouse IFN gamma Recombinant Protein	FA	14-8311	RUO
Rat IFN gamma Recombinant Protein	ELISA, FA	14-8315	RUO
Human IFN gamma Recombinant Protein	FA	14-8319	RUO
Mouse IFN gamma Recombinant Protein Carrier-Free	FA	34-8311	RUO
Human IFN gamma Recombinant Protein Carrier-Free	FA	34-8319	RUO
Mouse IFN gamma Single-Use ELISA RSG Standard	ELISA	39-8311	RUO
Human IFN gamma Single-Use ELISA RSG Standard	ELISA	39-8319	RUO
Recombinant Human IL-15		BMS319*	RUO
Mouse IL-15 Recombinant Protein	FA	14-8153	RUO
Human IL-15 Recombinant Protein	FA	14-8159	RUO
Mouse IL-15 Recombinant Protein Carrier-Free	FA	34-8153	RUO
Human IL-15 Recombinant Protein Carrier-Free	FA	34-8159	RUO
Mouse IL-15 Single-Use ELISA RSG Standard	ELISA	39-8151	RUO
Recombinant Mouse IL-15/IL-15R Complex Single-Use ELISA RSG Standard	ELISA	39-8152	RUO
Mouse IL-15/IL-15R Complex Recombinant Protein	FA	14-8152	RUO
Mouse IL-15/IL-15R Complex Recombinant Protein Carrier-Free	FA	34-8152	RUO

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents