NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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13 Item(s)

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Name Clone Application Cat. No. Reg.  

CD2 APC

RPA-2.10 FC 9017-0029 CE

CD3 APC

SK7 FC 9017-0036 CE

CD3 APC-eFluor® 780

SK7 FC 9047-0036 CE

CD7 APC

4H9 FC 9017-0078 CE

CD8 APC

SK1 FC 9017-0087 CE

CD8 APC-eFluor® 780

SK1 FC 9047-0087 CE

CD11b APC

ICRF44 FC 9017-0118 CE

CD27 APC

O323 FC 9017-0279 CE

CD38 APC-eFluor® 780

HB7 FC 9047-0388 CE

CD45 APC

2D1 FC 9017-9459 CE

CD45 APC-eFluor® 780

2D1 FC 9047-9459 CE

CD56 APC

CMSSB FC 9017-0567 CE

CD94 APC

HP-3D9 FC 9017-5094 CE

13 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents