NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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Name Clone Application Cat. No. Reg.  

Anti-Human CD45 APC

HI30 FC 17-0459 RUO

Anti-Human CD45 APC-eFluor® 780

HI30 FC 47-0459 RUO

Anti-Human CD45 Cyanine5

HI30 FC 19-0459 RUO

Anti-Rat CD45 APC

OX1 FC 17-0461 RUO

Anti-Rat CD45 APC-eFluor® 780

OX1 FC 47-0461 RUO

Anti-Mouse CD45.1 APC

A20 FC 17-0453 RUO

Anti-Mouse CD45.1 APC-eFluor® 780

A20 FC 47-0453 RUO

Anti-Mouse CD45.1 Cyanine5 (To Be Discontinued)

A20 FC 19-0453 RUO

Anti-Mouse CD45.2 Alexa Fluor® 700

104 FC 56-0454 RUO

Anti-Mouse CD45.2 APC

104 FC 17-0454 RUO

Anti-Mouse CD45.2 APC-eFluor® 780

104 FC 47-0454 RUO

Anti-Mouse CD49b (Integrin alpha 2) Alexa Fluor® 700

DX5 FC 56-5971 RUO

Anti-Mouse CD49b (Integrin alpha 2) APC

DX5 FC 17-5971 RUO

Anti-Human CD49b (Integrin alpha 2) APC

P1H5 FC 17-0500 RUO

Anti-Human CD56 (NCAM) APC-eFluor® 780

CMSSB FC 47-0567 RUO

CD56 APC

CMSSB FC 9017-0567 CE

CD56 APC

CMSSB 8017-0567 ASR

Anti-Human CD56 (NCAM) APC

CMSSB FC 17-0567 RUO

Anti-Human CD56 (NCAM) APC

MEM188 (MEM-188) FC 17-0569 RUO

Anti-Human CD57 eFluor® 660

TB01 (TBO1) FC 50-0577 RUO

Anti-Human CD62L (L-Selectin) APC

DREG-56 (DREG56) FC 17-0629 RUO

Anti-Human CD62L (L-Selectin) APC-eFluor® 780

DREG-56 (DREG56) FC 47-0629 RUO

Anti-Mouse CD62L (L-Selectin) Alexa Fluor® 700

MEL-14 FC 56-0621 RUO

Anti-Mouse CD62L (L-Selectin) APC

MEL-14 FC 17-0621 RUO

Anti-Mouse CD62L (L-Selectin) APC-eFluor® 780

MEL-14 FC 47-0621 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents