NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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Name Clone Application Cat. No. Reg.  

Anti-Human CD27 APC-eFluor® 780

O323 FC 47-0279 RUO

Anti-Mouse CD31 (PECAM-1) APC

390 FC 17-0311 RUO

Anti-Rat CD31 (PECAM-1) eFluor® 660

TLD-3A12 FC 50-0310 RUO

Anti-Human CD31 (PECAM-1) APC

WM-59 (WM59) FC 17-0319 RUO

Anti-Human CD31 (PECAM-1) APC-eFluor® 780

WM-59 (WM59) FC 47-0319 RUO

Anti-Human CD32 APC

6C4 (CD32) FC 17-0329 RUO

Anti-Rat CD38 eFluor® 660

14.27 FC 50-0380 RUO

Anti-Mouse CD38 Alexa Fluor® 700

90 FC 56-0381 RUO

Anti-Mouse CD38 APC

90 FC 17-0381 RUO

CD38 APC-eFluor® 780

HB7 FC 9047-0388 CE

CD38 APC-eFluor® 780

HB7 8047-0388 ASR

Anti-Human CD38 APC-eFluor® 780

HIT2 FC 47-0389 RUO

Anti-Human CD38 Alexa Fluor® 700

HIT2 FC 56-0389 RUO

Anti-Human CD38 APC

HIT2 FC 17-0389 RUO

Anti-Mouse CD40 APC

1C10 FC 17-0401 RUO

Anti-Human CD40 APC

5C3 FC 17-0409 RUO

Anti-Mouse/Rat CD40 APC

HM40-3 FC 17-0402 RUO

Anti-Human CD45 Alexa Fluor® 700

2D1 FC 56-9459 RUO

CD45 APC

2D1 FC 9017-9459 CE

Anti-Human CD45 APC

2D1 FC 17-9459 RUO

CD45 APC

2D1 FC 8017-9459 ASR

CD45 APC-eFluor® 780

2D1 FC 9047-9459 CE

CD45 APC-eFluor® 780

2D1 FC 8047-9459 ASR

Anti-Mouse CD45 Alexa Fluor® 700

30-F11 FC 56-0451 RUO

Anti-Mouse CD45 APC

30-F11 FC 17-0451 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents