NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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Name Clone Application Cat. No. Reg.  

Anti-Mouse CD8b APC-eFluor® 780

eBioH35-17.2 (H35-17.2) FC 47-0083 RUO

Anti-Human/Non-Human Primate CD8b eFluor® 660

SIDI8BEE FC 50-5273 RUO

Anti-Human CD11b (activation epitope) Alexa Fluor® 700

CBRM1/5 FC 56-0113 RUO

Anti-Human CD11b (activation epitope) APC

CBRM1/5 FC 17-0113 RUO

Anti-Human CD11b APC

ICRF44 FC 17-0118 RUO

CD11b APC

ICRF44 8017-0118 ASR

CD11b APC

ICRF44 FC 9017-0118 CE

Anti-Human CD11b APC-eFluor® 780

ICRF44 FC 47-0118 RUO

Anti-Mouse CD11b eFluor® 660

M1/70 FC 50-0112 RUO

Anti-Mouse CD11b Alexa Fluor® 700

M1/70 FC 56-0112 RUO

Anti-Mouse CD11b APC

M1/70 FC 17-0112 RUO

Anti-Mouse CD11b APC-eFluor® 780

M1/70 FC 47-0112 RUO

Anti-Mouse CD11b Cyanine5

M1/70 FC 19-0112 RUO

Anti-Rat CD11b/c eFluor® 660

OX42 FC 50-0110 RUO

Anti-Human CD16 Alexa Fluor® 700

eBioCB16 (CB16) FC 56-0168 RUO

Anti-Human CD16 APC

eBioCB16 (CB16) FC 17-0168 RUO

Anti-Human CD16 APC-eFluor® 780

eBioCB16 (CB16) FC 47-0168 RUO

Anti-Mouse CD16/CD32 Alexa Fluor® 700

93 FC 56-0161 RUO

Anti-Mouse CD16/CD32 APC

93 FC 17-0161 RUO

Anti-CD27 APC

LG.7F9 FC 17-0271 RUO

Anti-CD27 APC-eFluor® 780

LG.7F9 FC 47-0271 RUO

Anti-Human CD27 Alexa Fluor® 700

O323 FC 56-0279 RUO

CD27 APC

O323 8017-0279 ASR

CD27 APC

O323 FC 9017-0279 CE

Anti-Human CD27 APC

O323 FC 17-0279 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents