NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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Name Clone Application Cat. No. Reg.  

Anti-Mouse alpha GalCer:CD1d Complex PE

L363 FC 12-2019 RUO

Anti-Mouse Ly-49H PE

3D10 FC 12-5886 RUO

Anti-Human CD95 (APO-1/Fas) FITC

APO-1-1 FC BMS151FI* RUO

Anti-Human CD95 (APO-1/Fas) FITC

SM1/23 FC BMS140FI* RUO

Anti-Human CD8a PE-Cyanine7

SK1 FC 25-0087 RUO

Anti-Human CCL3 (MIP-1 alpha) FITC

CR3M FC 11-9706 RUO

Anti-Human CCL3 (MIP-1 alpha) PE

CR3M FC 12-9706 RUO

Anti-Mouse CCL3 (MIP-1 alpha) PE

DNT3CC FC 12-7532 RUO

Anti-Mouse CCL3 (MIP-1 alpha) PerCP-eFluor® 710

DNT3CC FC 46-7532 RUO

Anti-Human CCL4 (MIP-1 beta) PerCP-eFluor® 710

FL34Z3L FC 46-7540 RUO

Anti-Mouse CD2 FITC

RM2-5 FC 11-0021 RUO

Anti-Mouse CD2 PE

RM2-5 FC 12-0021 RUO

Anti-Human/Non-Human Primate CD2 FITC

RPA-2.10 FC 11-0029 RUO

Anti-Human/Non-Human Primate CD2 PE

RPA-2.10 FC 12-0029 RUO

Anti-Human/Non-Human Primate CD2 PE-Cyanine5

RPA-2.10 FC 15-0029 RUO

Anti-Human/Non-Human Primate CD2 PE-Cyanine7

RPA-2.10 FC 25-0029 RUO

Anti-Human/Non-Human Primate CD2 PerCP-eFluor® 710

RPA-2.10 FC 46-0029 RUO

Anti-Mouse CD3 PerCP-eFluor® 710

17A2 FC 46-0032 RUO

Anti-Rat CD3 FITC

eBioG4.18 (G4.18) FC 11-0030 RUO

Anti-Rat CD3 PE

eBioG4.18 (G4.18) FC 12-0030 RUO

Anti-Rat CD3 PerCP-eFluor® 710

eBioG4.18 (G4.18) FC 46-0030 RUO

Anti-Human CD3 FITC

HIT3a FC 11-0039 RUO

Anti-Human CD3 PE

HIT3a FC 12-0039 RUO

Anti-Human CD3 Alexa Fluor® 488

OKT3 FC 53-0037 RUO

Anti-Human CD3 FITC

OKT3 FC 11-0037 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents