NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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NK Cell Markers

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Name	Clone	Application	Cat. No.	Reg.
CD2 PerCP-eFluor® 710	RPA-2.10		8046-0029	ASR
CD2 PerCP-eFluor® 710	RPA-2.10	FC	9046-0029	CE
Anti-Human/Non-Human Primate CD2 FITC	RPA-2.10	FC	11-0029	RUO
CD2 FITC	RPA-2.10		8011-0029	ASR
CD2 FITC	RPA-2.10	FC	9011-0029	CE
Anti-Human/Non-Human Primate CD2 PE	RPA-2.10	FC	12-0029	RUO
CD2 PE	RPA-2.10		8012-0029	ASR
CD2 PE	RPA-2.10	FC	9012-0029	CE
Anti-Human/Non-Human Primate CD2 PE-Cyanine5	RPA-2.10	FC	15-0029	RUO
Anti-Human/Non-Human Primate CD2 PE-Cyanine7	RPA-2.10	FC	25-0029	RUO
CD2 PE-Cy7	RPA-2.10		8025-0029	ASR
CD2 PE-Cy7	RPA-2.10	FC	9025-0029	CE
Anti-Human/Non-Human Primate CD2 PerCP-eFluor® 710	RPA-2.10	FC	46-0029	RUO
Anti-Human CD11b PE-Cyanine5	ICRF44	FC	15-0118	RUO
Anti-Human CD11b PE-Cyanine7	ICRF44	FC	25-0118	RUO
Anti-Human CD11b PerCP-eFluor® 710	ICRF44	FC	46-0118	RUO
Anti-Human/Non-Human Primate CD16 PerCP-eFluor® 710	3G8	FC	46-0166	RUO
Anti-Human/Non-Human Primate CD62L (L-Selectin) FITC	SK11	FC	11-0625	RUO
CD62L (L-Selectin) FITC	SK11	FC	8011-0625	ASR
CD62L (L-Selectin) FITC	SK11	FC	9011-0625	CE

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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents