NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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Name Clone Application Cat. No. Reg.  

Anti-Human Granzyme B Purified

496B ICC, IHC 14-8889 RUO

Anti-Human phospho-NF kappa B p65 (S529) Purified

MCFA30 ELISA, IHC, WB 14-9864 RUO

Anti-AIM2 Purified

Polyclonal WB 14-6008 RUO

Anti-Human CD95 (APO-1/Fas) Purified

2R2 FC, FA BMS198* RUO

Anti-Human CD95 (APO-1/Fas) Purified

APO-1-1 FC, IHC BMS151* RUO

Recombinant Human sAPO-1/Fas

BMS314* RUO

Anti-Human CD95 (APO-1/Fas) Purified

SM 1-13 FC, ELISA BMS1030* RUO

Anti-Human CD95 (APO-1/Fas) Purified

SM1/1 FC, FA BMS138* RUO

Anti-Human CD95 (APO-1/Fas) Purified

SM1/23 FC, FA BMS140* RUO

Anti-Human/Non-Human Primate CD2 Purified

RPA-2.10 FC, IHC, FA, WB 14-0029 RUO

Anti-Human CD3 Purified

HIT3a FC 14-0039 RUO

Anti-Human CD3 Purified

OKT3 FC 14-0037 RUO

Anti-Human CD3 Purified

UCHT1 FC, IHC, FA 14-0038 RUO

Anti-Human CD7 Purified

eBio124-1D1 (124-1D1) FC 14-0079 RUO

Anti-Human CD8a Purified

C8/144B IHC 14-0085 RUO

Anti-Human CD8a Purified

HIT8a FC, IHC 14-0089 RUO

Anti-Human CD8a Purified

OKT8 (OKT-8) FC 14-0086 RUO

Anti-Human CD8a Purified

RPA-T8 FC, IHC 14-0088 RUO

Anti-Human/Non-Human Primate CD8b Purified

SIDI8BEE FC, IP, WB 14-5273 RUO

Anti-Human CD11b (activation epitope) Purified

CBRM1/5 FC, FA, IP 14-0113 RUO

Anti-Human CD11b Purified

ICRF44 FC, IHC, FA 14-0118 RUO

Anti-Human CD16 Purified

eBioCB16 (CB16) FC 14-0168 RUO

Anti-Human CD26 Purified

2A6 FC 14-0269 RUO

Anti-Human CD26 Purified

4H3 ELISA, IHC BMS1023* RUO

Anti-Human CD26 Purified

M-A261 FC, IHC, IP BMS143* RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents