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NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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Name Clone Application Cat. No. Reg.  

Anti-Human CD95 (APO-1/Fas) Purified

2R2 FC, FA BMS198* RUO

Anti-Human CD95 (APO-1/Fas) Purified

SM1/1 FC, FA BMS138* RUO

Anti-Human CD95 (APO-1/Fas) Purified

SM1/23 FC, FA BMS140* RUO

Mouse CCL3 (MIP-1 alpha) Recombinant Protein (To be Discontinued)

FA 14-8000 RUO

Anti-Mouse CD2 Purified

RM2-5 FC, IHC, FA 14-0021 RUO

Anti-Human/Non-Human Primate CD2 Purified

RPA-2.10 FC, IHC, FA, WB 14-0029 RUO

Anti-Mouse CD3 Purified

17A2 FC, IHC, IHC-F, FA 14-0032 RUO

Anti-Human CD3 Purified

UCHT1 FC, IHC, IHC-F, FA 14-0038 RUO

Anti-Mouse CD3e Purified

145-2C11 FC, IHC, IHC-F, FA, IP, WB 14-0031 RUO

Anti-Mouse CD3e Purified

eBio500A2 (500A2) FC, IHC-F, FA 14-0033 RUO

Anti-Rat CD8a Purified

OX8 FC, IHC, FA 14-0084 RUO

Anti-Rat CD8b Purified

eBio341 (341) FC, IHC, FA, IP, WB 14-0080 RUO

Anti-Human CD11b (activation epitope) Purified

CBRM1/5 FC, FA, IP 14-0113 RUO

Anti-Human CD11b Purified

ICRF44 FC, IHC, FA 14-0118 RUO

Anti-Mouse CD11b Purified

M1/70 FC, IHC, IHC-F, FA, IP 14-0112 RUO

Anti-Mouse CD16/CD32 Purified

93 FC, FA 14-0161 RUO

Anti-CD27 Purified

LG.7F9 FC, FA, IP 14-0271 RUO

Anti-Mouse CD38 Purified

90 FC, IHC, FA 14-0381 RUO

Anti-Mouse/Rat CD40 Purified

HM40-3 FC, IHC, FA 14-0402 RUO

Anti-Mouse CD45 Purified

30-F11 FC, IHC, FA, IP 14-0451 RUO

Anti-Mouse CD49b (Integrin alpha 2) Purified

HMa2 FC, IHC, IHC-F, FA, IP 14-0491 RUO

Anti-Human CD62L (L-Selectin) Purified

DREG-56 (DREG56) FC, IHC, IHC-F, FA, WB 14-0629 RUO

Anti-Mouse CD69 Purified

H1.2F3 FC, IHC, FA, IP 14-0691 RUO

Anti-Mouse CD71 (Transferrin Receptor) Purified

R17217 (RI7 217.1.4) FC, FA 14-0711 RUO

Anti-Human CD95 (APO-1/Fas) Purified

DX2 FC, IHC, FA 14-0959 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents