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NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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Name Clone Application Cat. No. Reg.  

Anti-Rat CD3 Purified

eBioG4.18 (G4.18) FC, IHC, IP, WB 14-0030 RUO

Anti-Mouse CD3e Purified

145-2C11 FC, IHC, IHC-F, FA, IP, WB 14-0031 RUO

Anti-Mouse CD8a Purified

53-6.7 FC, IHC, IHC-F, IP 14-0081 RUO

Anti-Rat CD8b Purified

eBio341 (341) FC, IHC, FA, IP, WB 14-0080 RUO

Anti-Mouse CD8b Purified

eBioH35-17.2 (H35-17.2) FC, IHC, IHC-F, IP 14-0083 RUO

Anti-Human/Non-Human Primate CD8b Purified


Anti-Human CD11b (activation epitope) Purified

CBRM1/5 FC, FA, IP 14-0113 RUO

Anti-Mouse CD11b Purified

M1/70 FC, IHC, IHC-F, FA, IP 14-0112 RUO

Anti-Human CD26 Purified

M-A261 FC, IHC, IP BMS143* RUO

Anti-Human/Mouse CD27 Purified

LG.3A10 FC, IHC, IP 14-0272 RUO

Anti-CD27 Purified

LG.7F9 FC, FA, IP 14-0271 RUO

Anti-Mouse CD31 (PECAM-1) Purified

390 FC, IHC, IHC-F, IP 14-0311 RUO

Anti-Mouse CD40 Purified

1C10 FC, IHC, IP 14-0401 RUO

Anti-Mouse CD45 Purified

30-F11 FC, IHC, FA, IP 14-0451 RUO

Anti-Mouse CD45.1 Purified

A20 FC, IP 14-0453 RUO

Anti-Mouse CD45.2 Purified

104 FC, IHC, IHC-F, IP 14-0454 RUO

Anti-Mouse CD49b (Integrin alpha 2) Purified

HMa2 FC, IHC, IHC-F, FA, IP 14-0491 RUO

Anti-Mouse CD69 Purified

H1.2F3 FC, IHC, FA, IP 14-0691 RUO

Anti-Mouse CD107a (LAMP-1) Purified

eBio1D4B (1D4B) FC, IHC, IHC-F, IHC-P, IP, WB 14-1071 RUO

Anti-Mouse CD107b (LAMP-2) Purified

eBioABL-93 (ABL-93) FC, IHC, IP 14-1072 RUO

Anti-Mouse CD120b (TNF Receptor II) Purified

TR75-54 FC, ELISA, FA, IP, WB 14-1203 RUO

Anti-Mouse CD122 Purified (Discontinued; refer to Cat. No. 14-1222)

5H4 FC, IP 14-1221 RUO

Anti-Mouse CD122 Purified

TM-b1 (TM-beta1) FC, FA, IP 14-1222 RUO

Anti-Mouse CD160 Purified

eBioCNX46-3 (CNX46-3) FC, FA, IP, WB 14-1601 RUO

Anti-Human CD218a (IL-18 Receptor alpha) Purified (Discontinued)

H44 FC, IHC, IP, WB 14-7183 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents