NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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NK Cell Markers

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Name	Clone	Application	Cat. No.	Reg.
Anti-Human CD107a (LAMP-1) PE-Cyanine5	eBioH4A3	FC	15-1079	RUO
Anti-Human CD95 (APO-1/Fas) PE-Cyanine5	DX2	FC	15-0959	RUO
Anti-Human CD62L (L-Selectin) PE-Cyanine5	DREG-56 (DREG56)	FC	15-0629	RUO
Anti-Human CD56 (NCAM) PE-Cyanine5	CMSSB	FC	15-0567	RUO
Anti-Human CD45 PE-Cyanine5	HI30	FC	15-0459	RUO
Anti-Human CD38 PE-Cyanine5	HIT2	FC	15-0389	RUO
Anti-Human CD27 PE-Cyanine5	O323	FC	15-0279	RUO
Anti-Human CD16 PE-Cyanine5	eBioCB16 (CB16)	FC	15-0168	RUO
Anti-Human CD11b PE-Cyanine5	ICRF44	FC	15-0118	RUO
Anti-Human CD8a PE-Cyanine5	RPA-T8	FC	15-0088	RUO
Anti-Human CD3 PE-Cyanine5	UCHT1	FC	15-0038	RUO
Anti-Human/Non-Human Primate CD2 PE-Cyanine5	RPA-2.10	FC	15-0029	RUO

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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents