NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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NK Cell Markers

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Name	Clone	Application	Cat. No.	Reg.
ZAP-70 (2F3.2) PE	2F3.2		8012-9945	ASR
ZAP-70 (1E7.2) PE	1E7.2		8012-6695	ASR
CD305 (LAIR1) PE	NKTA255	FC	8012-3059	ASR
CD56 PE	CMSSB		8012-0567	ASR
CD45 PE	2D1	FC	8012-9459	ASR
CD38 PE	HB7		8012-0388	ASR
CD30 PE	Ber-H2		8012-0309	ASR
CD26 PE	2A6		8012-0269	ASR
CD16 PE	CB16		8012-0168	ASR
CD11b PE	ICRF44		8012-0118	ASR
CD8 PE	SK1		8012-0087	ASR
CD3 PE	SK7	FC	8012-0036	ASR
CD2 PE	RPA-2.10		8012-0029	ASR

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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents