NK / NKT Cells

Natural Killer (NK) cells are important effector lymphocytes of innate immunity that exhibit cytolytic activity against a variety of allogeneic targets in a non-specific, contact-dependent, nonphagocytic process which does not require prior sensitization to antigen. NK cells share several properties with conventional cytotoxic T cells (CTL), including similar mechanisms for cytolysis. Cytolytic activity is mediated by secretion of pore-forming proteins such as Granzyme B and Perforin, serine proteases and other proteins. NK cytotoxic activity is positively regulated by IL-2, IL-15 and interferons; and is diminished by prostaglandins and TGF-beta.

Natural Killer T (NKT) cells represent a distinct lineage of T cells that express an invariant alpha/beta T cell receptor (TCR) and share a number of cell surface markers in common with NK cells. NKT cells are activated by glycolipid antigens presented by CD1d. Expression of CD160 and Valpha24Jalpha18 TCR can be used for the identification of mouse and human NKT cells, respectively.

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NK Cell Markers

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Name	Clone	Application	Cat. No.	Reg.
Anti-Human CD3 Alexa Fluor® 488	OKT3	FC	53-0037	RUO
Anti-Mouse CD3e Alexa Fluor® 488	145-2C11	FC	53-0031	RUO
Anti-Mouse CD8a Alexa Fluor® 488	53-6.7	FC	53-0081	RUO
Anti-Human CD8a Alexa Fluor® 488	OKT8 (OKT-8)	FC	53-0086	RUO
Anti-Mouse CD8b Alexa Fluor® 488	eBioH35-17.2 (H35-17.2)	FC	53-0083	RUO
Anti-Mouse CD11b Alexa Fluor® 488	M1/70	FC	53-0112	RUO
Anti-Human CD56 (NCAM) Alexa Fluor® 488	CB56	FC	53-0568	RUO
Anti-Mouse CD95 (APO-1/Fas) Alexa Fluor® 488	15A7	FC	53-0951	RUO
Anti-Mouse CD107a (LAMP-1) Alexa Fluor® 488	eBio1D4B (1D4B)	FC	53-1071	RUO
Anti-Human CD107a (LAMP-1) Alexa Fluor® 488	eBioH4A3	FC	53-1079	RUO
Anti-Mouse CD107b (LAMP-2) Alexa Fluor® 488	eBioABL-93 (ABL-93)	FC	53-1072	RUO
Anti-Human CD107b (LAMP-2) Alexa Fluor® 488	eBioH4B4 (H4B4)	FC	53-1078	RUO
Anti-Human CD160 Alexa Fluor® 488	BY55	FC	53-1609	RUO
Anti-Human CD161 Alexa Fluor® 488	HP-3G10	FC	53-1619	RUO
Anti-Mouse EOMES Alexa Fluor® 488	Dan11mag	FC	53-4875	RUO
Anti-Human IFN gamma Alexa Fluor® 488	4S.B3	FC	53-7319	RUO
Anti-Mouse IFN gamma Alexa Fluor® 488	XMG1.2	FC	53-7311	RUO
Anti-Human LAP (Latency Associated Peptide) Alexa Fluor® 488	TW4-2F8	FC	53-9828	RUO
Anti-Human MICA/B Alexa Fluor® 488	6D4	FC	53-5788	RUO
Anti-Human TNF alpha Alexa Fluor® 488	MAb11	FC	53-7349	RUO
Anti-Mouse TNF alpha Alexa Fluor® 488	MP6-XT22	FC	53-7321	RUO

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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents