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Hematopoietic Stem Cells

It is now known that Hematopoietic Stem Cells (HSCs) progress through defined stages of maturation that result in gradual loss of multi-lineage potential, and commitment to various blood cell phenotypes. Mouse HSCs were first isolated as part of the bone marrow fraction depleted of lineage positive cells. Subsequently, it was discovered that the lineage-negative fraction could be significantly enriched for HSCs by further selecting the lin-Sca-1+c-Kit+ (LSK) population of bone marrow. In 2005, it was demonstrated by Morrison et al that a combination of the SLAM family of proteins could also be used to efficiently identify and isolate HSCs. They found the CD150+CD48-CD244-CD41- fraction of mouse bone marrow to be significantly enriched for long-term reconstituting ability. In humans, the isolation of a lin-CD34+CD90+ progenitor cell resulted in the purification of a homogeneous HSC population. The critical test for HSCs is in their ability to clinically rescue myelo-ablated hosts from hematopoietic failure, and establish long-term multi-hematopoietic lineage reconstitution.

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Name Clone Application Cat. No. Reg.  

Anti-Mouse CD41 Purified

eBioMWReg30 (MWReg30) FC, ELISA, FA, IP 14-0411 RUO

Recombinant Human CD44 Std


Human sCD93 ELISA Ready-SET-Go!®

ELISA 88-50340 RUO

Anti-Human CD93 Purified

R139 FC, ELISA, IHC, IP, WB 14-0939 RUO

Human sCD105 (Endoglin) Instant ELISA


Human G-CSF Instant ELISA


Human TIE-2 Platinum ELISA


Monkey sVE-cadherin Matched Antibody Pairs


Human VEGF-R3/FLT-4 Platinum ELISA


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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents