Hematopoietic Stem Cells

It is now known that Hematopoietic Stem Cells (HSCs) progress through defined stages of maturation that result in gradual loss of multi-lineage potential, and commitment to various blood cell phenotypes. Mouse HSCs were first isolated as part of the bone marrow fraction depleted of lineage positive cells. Subsequently, it was discovered that the lineage-negative fraction could be significantly enriched for HSCs by further selecting the lin-Sca-1+c-Kit+ (LSK) population of bone marrow. In 2005, it was demonstrated by Morrison et al that a combination of the SLAM family of proteins could also be used to efficiently identify and isolate HSCs. They found the CD150+CD48-CD244-CD41- fraction of mouse bone marrow to be significantly enriched for long-term reconstituting ability. In humans, the isolation of a lin-CD34+CD90+ progenitor cell resulted in the purification of a homogeneous HSC population. The critical test for HSCs is in their ability to clinically rescue myelo-ablated hosts from hematopoietic failure, and establish long-term multi-hematopoietic lineage reconstitution.

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Name Clone Application Cat. No. Reg.  

Anti-Mouse CD41 Purified

eBioMWReg30 (MWReg30) FC, ELISA, FA, IP 14-0411 RUO

Recombinant Human CD44 Std

ELISA BMS318* RUO

Human sCD93 ELISA Ready-SET-Go!®

ELISA 88-50340 RUO

Anti-Human CD93 Purified

R139 FC, ELISA, IHC, IP, WB 14-0939 RUO

Anti-Human CD93 Biotin

R3 FC, ELISA 13-0938 RUO

Human sCD105 (Endoglin) Instant ELISA

ELISA BMS2105INST* RUO

Human G-CSF Instant ELISA

ELISA BMS2001INST* RUO

Human TIE-2 Platinum ELISA

ELISA BMS2042* RUO

Monkey sVE-cadherin Matched Antibody Pairs

ELISA BMS652MST* RUO

Human sVE-cadherin Matched Antibody Pairs

ELISA BMS253MST* RUO

Human VE-Cadherin Instant ELISA

ELISA BMS253INST* RUO

Monkey sVE-cadherin Platinum ELISA

ELISA BMS652* RUO

Human sVE-cadherin Platinum ELISA

ELISA BMS253* RUO

Anti-Human CD144 (VE-Cadherin) Purified

polyclonal FC, ELISA, IHC, WB BMS158* RUO

Human VEGF-R3/FLT-4 Platinum ELISA

ELISA BMS2064* RUO

15 Item(s)

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents