Anti-Canine MHC Class II Alexa Fluor® 647

Also known as: MHC II

Clone: YKIX334.2

RUO: For Research Use Only. Not for use in diagnostic procedures.

SKU# 51-5909

Cat. No.	Size
51-5909-41	25 tests
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Staining of normal canine peripheral blood cells with Rat IgG2a K Isotype Control Alexa Fluor® 647...View More

Description

Description: This YKIX334.2 monoclonal antibody reacts with canine major histocompatibility complex (MHC) Class II. The MHC plays a significant role in immunity by presenting self and non-self antigens to T cells. In dogs, MHC Class II is expressed on all T and B cells, macrophages, fibroblasts, and kidney interstitial cells.

This monoclonal antibody has been reported to inhibit mixed lymphocyte reactions and T cell activation induced by MHC Class II antigen presentation in vitro. Also, YKIX334.2 recognition of MHC Class II is not allele-specific.

Details

Host	Rat
Isotype	IgG2a, kappa
Reactivity	Canine
Conjugate	Alexa Fluor 647
Laser	Red Laser
Emit	668 nm
Excite	633 - 647 nm
Legal	Alexa Fluor® and Pacific Blue® are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only. This product is subject to an agreement between Molecular Probes, Inc. and eBioscience, and the manufacture, use, sale or import of this product may be subject to one or more U.S. patents, pending applications and corresponding foreign equivalents, owned by Molecular Probes, Inc. (a wholly owned subsidiary of Invitrogen Corp). The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product for life science research or as an ASR. The buyer cannot use this product for manufacturing or for any other screening (specifically including use in combination with microarrays or High Content Screening) or testing purpose, other than as an ASR. For information on purchasing a license to this product for purposes other than life science research or use as an ASR, contact Molecular Probes, Inc.
Reported Applications	Flow Cytometric Analysis

Documentation

TDS Link	Download TDS

Additional Formats

Cat. No.	Name	Excite	Emit	Application	Reg.
11-5909	Anti-Canine MHC Class II FITC	488 nm		FC	RUO

Related Products

Cat. No.	Name	Excite	Emit	Application	Reg.
51-4321	Rat IgG2a K Isotype Control Alexa Fluor® 647 (To Be Discontinued. Refer to Cat. No. 50-4321)	633 - 647 nm	668 nm	FC, ICC, IHC	RUO

References

References: Bismarck D, Schütze N, Moore P, Büttner M, Alber G, Buttlar HV. Canine CD4(+)CD8(+) double positive T cells in peripheral blood have features of activated T cells. Vet Immunol Immunopathol. 2012 Oct 15;149(3-4):157-66 (YKIX334.2, FC, Pubmed)

Cobbold S, Metcalfe S. Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens. 1994 Mar;43(3):137-54. (YKIX334.2, FC)

Rabanal RM, Ferrer L, Else RW. Immunohistochemical detection of canine leucocyte antigens by specific monoclonal antibodies in canine normal tissues. Vet Immunol Immunopathol. 1995 Jul;47(1-2):13-23.

Doveren RF, van der Linden CJ, Spronken EE, Groenewegen G, Buurman WA. Canine MHC-class II antigens on B and T lymphocytes. Tissue Antigens. 1986 Feb;27(2):87-98.

View More Products

Antigens	Area of Biology	Cell Type	Formats
MHC Class II	Adaptive Immunity Innate Immunity	B Cells Dendritic Cells Macrophage & Monocyte Cells	Alexa Fluor 647