Anti-Canine CD8a APC

Description: This YCATE55.9 monoclonal antibody reacts with canine CD8 alpha. This cell surface receptor is expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). In dogs, CD8 alpha is expressed on thymocytes, a subset of mature T cells, NK cells, and intestinal intraepithelial lymphocytes (IELs). CD8 binds to MHC class I and plays a role in thymocyte development and mature T cell activation.

This monoclonal antibody has been reported to inhibit cytotoxic T cell generation and function in vitro. In addition, this antibody has been reported to be immunosuppressive in vivo.

References: Bismarck D, Schütze N, Moore P, Büttner M, Alber G, Buttlar HV. Canine CD4(+)CD8(+) double positive T cells in peripheral blood have features of activated T cells. Vet Immunol Immunopathol. 2012 Oct 15;149(3-4):157-66 (YCATE55.9, FC, Pubmed)

Lin YC, Huang YC, Wang YS, Juang RH, Liao KW, Chu RM. Canine CD8 T cells showing NK cytotoxic activity express mRNAs for NK cell-associated surface molecules. Vet Immunol Immunopathol. 2010 Feb 15;133(2-4):144-53.

Elwood CM, Hamblin AS, Batt RM. Quantitative and qualitative immunohistochemistry of T cell subsets and MHC class II expression in the canine small intestine. Vet Immunol Immunopathol. 1997 Sep 19;58(3-4):195-207.

Cobbold S, Metcalfe S. Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens. 1994 Mar;43(3):137-54. (YCATE55.9, FC)

Watson CJ, Cobbold SP, Davies HS, Rebello PR, Thiru S, McNair R, Rasmussen A, Waldmann H, Calne RY, Metcalfe SM. Immunosuppression of canine renal allograft recipients by CD4 and CD8 monoclonal antibodies. Tissue Antigens. 1994 Mar;43(3):155-62. (YCATE55.9, FA)