Anti-Canine CD4 APC

Description: The YKIX302.9 monoclonal antibody reacts with canine CD4, a cell surface receptor expressed on a majority of thymocytes, a subpopulation of mature T cells and dendritic cells. In dogs, CD4 is also highly expressed on neutrophils. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role in T cell development and homeostasis.

This YKIX302.9 monoclonal antibody has been reported to block MHC II-restricted T cell responses in vivo and in vitro.

References: Bismarck D, Schütze N, Moore P, Büttner M, Alber G, Buttlar HV. Canine CD4(+)CD8(+) double positive T cells in peripheral blood have features of activated T cells. Vet Immunol Immunopathol. 2012 Oct 15;149(3-4):157-66 (YKIX302.9, FC, Pubmed)

Cobbold S, Metcalfe S. Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens. 1994 Mar;43(3):137-54. (YKIX302.9, FC)

Watson CJ, Cobbold SP, Davies HS, Rebello PR, Thiru S, McNair R, Rasmussen A, Waldmann H, Calne RY, Metcalfe SM. Immunosuppression of canine renal allograft recipients by CD4 and CD8 monoclonal antibodies. Tissue Antigens. 1994 Mar;43(3):155-62. (YKIX302.9, FA)