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The InstantOne™ ELISA is specifically engineered for accurate measurement of total and phosphorylated human and mouse c-Jun (Ser73) in cell lysates. Detection of rat c-Jun is also expected. The InstantOne™ ELISA kit allows for fast analysis of samples in approximately one hour. All reagents used in a traditional sandwich ELISA are added in solution to a plate followed by a wash step and detection with the TMB colorimetric substrate.
c-Jun is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : JUN
Protein Aliases : Activator protein 1, AH119, AP1, enhancer-binding protein AP1, immediate early, Jun A, Jun activation domain binding protein, Jun oncogene, jun proto-oncogene, p39, Proto-oncogene c-Jun, transcription factor AP-1, Transcription factor AP-1 subunit Jun, Transcription factor Jun, V-jun avian sarcoma virus 17 oncogene homolog, v-jun sarcoma virus 17 oncogene homolog
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