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Transcription Factors

Transcription factors are DNA-binding proteins, bound to specific DNA sequences that regulate gene expression.  Whether activating or repressing gene regulation, these proteins control the transfer of genetic information from DNA to RNA.  Transcription factor modulation of target genes leads to new molecules appearing on an immune cell’s surface, including receptors for cytokines that stimulate cell proliferation and differentiation. The mechanisms regulating the signaling pathways in the immune system are diverse and complicated.  A greater understanding of the presence and regulation control of transcription factors in immune cells may provide novel therapeutic opportunities for immune diseases.

Detection of transcription factors in immune cell populations, particularly in populations at low frequencies and in a heterogeneous environment, may be challenging when using classical methods such as western blot analysis.  Employing an application such as flow cytometry, that permits the characterization of transcription factors within discreet immune cell subpopulations, delivers a powerful approach to analyzing immune response.

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Name Clone Application Cat. No. Reg.  

Anti-Mouse AHR Alexa Fluor® 488

4MEJJ FC 53-5925 RUO

Anti-Mouse AHR eFluor® 660

4MEJJ FC 50-5925 RUO

Anti-Mouse AHR PE

4MEJJ FC 12-5925 RUO

Anti-Mouse AHR PE-Cyanine7

4MEJJ FC 25-5925 RUO

Anti-Human AHR eFluor® 660

FF3399 FC 50-9854 RUO

Anti-Human AHR PE

FF3399 FC 12-9854 RUO

Anti-Human AHR PE-Cyanine7

FF3399 FC 25-9854 RUO

Anti-Human AHR PerCP-eFluor® 710

FF3399 FC 46-9854 RUO

Anti-Human AHR Purified

FF3399 FC, ICC, IHC, IHC-P, WB 14-9854 RUO

Anti-Mouse Aiolos eFluor® 660

8B2 FC 50-5789 RUO

Anti-Mouse Aiolos PE

8B2 FC 12-5789 RUO

Anti-Mouse Aiolos Purified

8B2 WB 14-5789 RUO

Anti-Mouse AIRE eFluor® 660

5H12 FC, IHC, IHC-F 50-5934 RUO

Anti-Mouse AIRE Alexa Fluor® 488

5H12 FC, IHC, IHC-F 53-5934 RUO

Anti-Mouse AIRE Purified

5H12 FC, IHC, IHC-F, IP, WB 14-5934 RUO

Anti-Human AIRE Purified

TM-724 ICC, IHC, IHC-F, IHC-P 14-9534 RUO

Anti-Human Foxp3 PE-Cyanine7

PCH101 FC 25-4776 RUO

Anti-Human BATF eFluor® 660

MBM7C7 FC 50-9860 RUO

Anti-Human BATF PerCP-eFluor® 710

MBM7C7 FC 46-9860 RUO

Anti-Human BATF PE

MBM7C7 FC 12-9860 RUO

Anti-Mouse Bcl-6 PerCP-eFluor® 710

BCL-DWN FC 46-5453 RUO

Anti-Human/Mouse Bcl-6 Purified

GI191E IHC, IHC-P, WB 14-9887 RUO

Anti-Human Bcl-6 APC

BCL-UP FC 17-9880 RUO

Anti-Human Bcl-6 PerCP-eFluor® 710

BCL-UP FC 46-9880 RUO

Anti-Human/Mouse beta-Catenin Alexa Fluor® 488

15B8 FC 53-2567 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents