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Adaptive Immunity

Adaptive immunity is defined by the invocation of a specific cellular immune response, in contrast to innate immunity that is distinguished by a non-specific immunity.  Adaptive responses involve lymphocytes and are characterized two ways, humoral and cell-mediated immunity. B cells mediate a humoral response, the creation of antibodies to bind specifically to foreign antigens including bacteria, and microbial toxins. Cell-mediated immunity is a more complex system involving the production of cytotoxic T-lymphocytes, activated macrophages, activated NK cells, and cytokine release in response to an antigen and is mediated by T-lymphocytes. T cells recognize a pathogen only after antigens (small fragments of the pathogen) have been processed and presented typically in combination with a “self” receptor called a major histocompatibility complex (MHC) molecule. Cell-mediated immunity is important in combating intracellular organisms, performing tumor surveillance, mediating transplant rejection, and fighting fungal and viral infections.

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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents