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VEGF-A

Alias: Vascular Endothelial Growth Factor A

VEGF-A is a growth factor and the central mediator that promotes angiogenesis. VEGFA is active in angiogenesis, vascularization, and endothelial cell growth/survival. It stimulates the secretion and activation of extracellular matrix degrading enzymes. VEGF helps maintain immature vascularization and induces various anti-apoptotic proteins such as Bcl-2 and A1 that help promote cell survival. VEGF also induces angiogenic effects on endothelial cells by binding to the receptor tyrosine kinases VEGFR1/FLT1 and VEGFR2/KDR where it activates various signaling pathways that include Ras/ERK, p38, FAK, PLCγ, and PI3K/AKT. Additionally, VEGF has a potent roll in neovascularization of tumors. Various tumor cell types express VEGF which helps maintains it viability and vascularization. VEGFA consists of various isoforms that include VEGF121 that is acidic and is freely secreted. VEGF145 and VEGF165 that binds to Neuropilin-1 , and VEGF189 is cell associated after secretion and released as a soluble form by heparin or plasmin.

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19 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

ProcartaPlex Canine Cytokine/Chemokine/Growth Factor Panel 1 (11 plex)

Multiplex EPX11A-50511 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Growth Factor Panel (11plex)

Multiplex EPX110-12170 RUO

ProcartaPlex NHP Growth Factor Panel (7 plex)

Multiplex EPX070-40043 RUO

ProcartaPlex Rat Kidney Toxicity Panel 1 (5 plex)

Multiplex EPX050-30124 RUO

Platinum ProcartaPlex Human Panel 1 (42 plex)

Multiplex EPXP420-10200 RUO

Platinum ProcartaPlex Human 42plex Control Set

Multiplex EPXP420-10200* RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

Human VEGF-A Platinum ELISA

ELISA BMS277/2CE* CE

Mouse VEGF-A Platinum ELISA

ELISA BMS619/2* RUO

Human VEGF-A Platinum ELISA

ELISA BMS277/2* RUO

Platinum ProcartaPlex Human VEGF-A Simplex

Multiplex EPXP010-10277 RUO

ProcartaPlex Mouse VEGF-A Simplex

Multiplex EPX01A-20619 RUO

ProcartaPlex Canine VEGF-A Simplex

Multiplex EPX01A-50277 RUO

ProcartaPlex Rat VEGF-A Simplex

Multiplex EPX01A-30619 RUO

ProcartaPlex Human VEGF-A Simplex

Multiplex EPX01A-10277 RUO

ProcartaPlex NHP VEGF-A Simplex

Multiplex EPX01A-40277 RUO

19 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents