TNF beta
Alias: TNFβ, Tumor Necrosis Factor beta, Lymphotoxin alpha, LTA
TNFβ is a TH1 cytokine that can either for a homotrimer or heterodimerize with LTB. In its homotrimer form, TNFβ binds to various receptors that include TNFR1, TNFBR, and TNFRSF14. In its hetrodimeric form with LTB, TNFβ binds to LTBR (TNFRSF3). TNFβ is produced by activated lymphocytes where it is induced in an antigen-specific MHC restricted fashion from class I and class II restricted T cells as well as by lymphoid tissues during viral infections. TNFβ has several effects on target cells that includes killing, proliferation, differentiation and induction of adhesion molecule (ICAM-1) expression. TNFβ participates in tumor immunity, and it has been reported to inhibit carcinogenesis as well as growth of some tumors in vivo.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents
