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TNF alpha

Alias: TNFα, Tumor Necrosis Factor alpha

TNFα is a pleiotropic cytokine that plays key roles in innate and adaptive immunity. TNFα is widely implicated in numerous immune responses and regulations, though TNFα is most often associated with regulation of cell survival and pro-inflammatory properties. TNFα is known to induce cellular proliferation/differentiation, tumorigenesis, apoptotic or necrotic cell death (including certain tumor cell lines), immunoregulatory activities, lipid metabolism, coagulation and endothelial function. Its pro-inflammatory properties lead to the recruitment and activation of inflammatory cells to the site of injury where it is known to induce various cytokines that include IL-1, IL-6, IL-8, MCP-1, and RANTES. TNFα is primarily expressed by macrophages and monocytes, but is also expressed by neutrophils, NK-cells, mast-cells, endothelial cells, activated lymphocytes, and various tissue-specific cell types including certain cancers. TNFα is expressed as membrane-bound homotrimer protein that is cleaved by ADAM17 that allows for its release into the blood stream. TNFα binds to two distinctly different type I transmembrane glycoprotein receptors, TNFR1 and TNFR2, that bind to the soluble and membrane-bound forms of TNFα with different affinities. TNFα is associated with numerous diseases due to its role in inflammation and autoimmunity that include rheumatoid arthritis (RA), inflammatory bowel disease (IBS), psoriasis, and multiple sclerosis (MS). Developments of TNFα neutralizing treatments have severely help treat many of these diseases.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Porcine Cytokine & Chemokine Panel 1 (9 plex)

Multiplex EPX090-60829 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex Canine Cytokine/Chemokine/Growth Factor Panel 1 (11 plex)

Multiplex EPX11A-50511 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Rat Cytokine & Chemokine Panel (22 plex)

Multiplex EPX220-30122 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1 (26 plex)

Multiplex EPXR260-26088 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

eZKine™ CD8 Activation 2 Whole Blood Intracellular Cytokine Kit

FC 8822-6855 RUO

eZKine™ Th1 Activation 2 Whole Blood Intracellular Cytokine Kit

FC 8822-6852 RUO

ProcartaPlex Mouse High Sensitivity Panel (5 plex)

Multiplex EPXS050-22199 RUO

ProcartaPlex Human High Sensitivity Panel (9 plex)

Multiplex EPXS090-12199 RUO

ProcartaPlex Human High Sensitivity TNF alpha Simplex

Multiplex EPXS010-10223 RUO

ProcartaPlex Human Inflammation Panel (20 plex)

Multiplex EPX200-12185 RUO

ProcartaPlex Mouse Myokine Panel (5 plex)

Multiplex EPX050-20833 RUO

ProcartaPlex Human Myokine Panel (8 plex)

Multiplex EPX080-12186 RUO

Platinum ProcartaPlex Human Panel 1 (42 plex)

Multiplex EPXP420-10200 RUO

Platinum ProcartaPlex Human Panel 2 (13 plex)

Multiplex EPXP130-10100 RUO

Platinum ProcartaPlex Human 42plex Control Set

Multiplex EPXP420-10200* RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents