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TGF beta 1

Alias: Transforming Growth Factor beta-1

TGFβ is a pleiotropic immunoregulatory cytokine that controls immune responses. TGFβ1 is highly expressed in platelets and also produced by macrophages, lymphocytes, endothelial cells, chondrocytes, and leukemic cells. TGFβ is produced in a pro-form (pro-TGFβ) and is intracellularly cleaved by furin into latent TGFβ. Latent TGFβ is a non-covalently associated complex consisting of Latency-Associated Peptide (LAP) that is the N-terminal portion of pro-TGFβ and the mature TGFβ that is made of the C-terminus of pro-TGFβ. TGFβ is secreted as an inactive (latent) form in a complex with two proteins; LAP (Latency Activated Peptide) and LTBP (Latent TFGβ Binding Protein). Disassociation from this complex is required for its activation that occurs through various means that include low pH, reactive oxygen species, proteases, and several integrins. In this latent form, TGFβ cannot bind the TGFβ receptor and requires activation to become biologically active. In its active form, TGFβ binds to a heterodimeric receptor serine/threonine kinase complex that is comprised of TGFβR1 and TGFβRII. The binding of TGFβ to its receptor results in the phosphorylation/activation of the transcription factors SMAD2/3 that leads to their binding to SMAD4 and subsequent translocation to the nucleus. TGFβ activities include the inhibition of cell growth in epithelial cells, endothelial cells, fibroblasts, neurons, NK cells, T cells, and other hematopoietic cell types. TGFβ1 also downregulates the activities of activated macrophages and blocks the anti-tumor activity of IL-2 – bearing lymphokine-activated killer (LAK) cells. TGFβ1 has also been found to have a critical role in the development of TReg cells and act as a co-stimulatory factor for expression of Foxp3. These TGFβ1-induced regulatory T cells have been termed iTReg. Additionally, TGFβ1 and IL-6 together, can induce differentiation of mouse naive T cells into TH17 cells.

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18 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

Mouse LAP (TGF beta 1) Ready-SET-Go!

ELISA 88-50690 RUO

Rat LAP (TGF beta 1) Ready-SET-Go!

ELISA 88-50680 RUO

Rat TGF-beta1 Platinum ELISA

ELISA BMS623/3* RUO

Human TGF-beta1 Platinum ELISA

ELISA BMS249/4* RUO

Mouse TGF-beta1 Platinum ELISA

ELISA BMS608/4* RUO

Human/Mouse TGF beta 1 ELISA Ready-SET-Go! (2nd Generation)

ELISA 88-8350 RUO

ProcartaPlex Human TGF beta 1 Simplex

Multiplex EPX01A-10249 RUO

ProcartaPlex Porcine TGF beta 1 Simplex

Multiplex EPX01A-60249 RUO

ProcartaPlex NHP TGF beta 1 Simplex

Multiplex EPX01A-40249 RUO

ProcartaPlex Mouse TGF beta 1 Simplex

Multiplex EPX01A-20608 RUO

ProcartaPlex Canine TGF beta 1 Simplex

Multiplex EPX01A-50249 RUO

ProcartaPlex Rat TGF beta 1 Simplex

Multiplex EPX01A-30249 RUO

Human TGF beta 1 Recombinant Protein

ELISA, FA 14-8348 RUO

Human TGF beta 1 Recombinant Protein Carrier-Free

FA 34-8348 RUO

Anti-TGF beta Functional Grade Purified

1D11.16.8 IHC, FA 16-9243 RUO

Mouse TGF beta 1 Recombinant Protein

FA 14-8342 RUO

Mouse TGF beta 1 Recombinant Protein Carrier-Free

FA 34-8342 RUO

Human TGF beta 1 Single-Use ELISA RSG Standard (2nd Generation)

ELISA 39-8343 RUO

18 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents