Musashi 1 regulates expression of the NOTCH1 antagonist NUMB by binding RNA sequences. It is a 39 kDa RNA binding protein expressed in Central Nervous System (CNS) stem and progenitor cells with decreased expression when undergoing differentiation. Evidence suggests it is also expressed in stem cells and a variety of other tissues such as the gut, stomach, mammary gland and hair follicles. In addition to normal tissue expression, Musashi-1 has been identified in cells from several tumor types, mainly pulmonary and adenocarcinoma, as well as large and small cell carcinomas. Musashi 1 may also play a role in the proliferation and maintenance of stem cells of the central nervous system. Recently, expression in ischemic lesions following stroke provides evidence for neurogenesis as well as regulating apoptosis.
|14H1||ICC, IHC, IHC-P, WB||14-9896||RUO|
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents