The clearance of apoptotic cells is critical for both tissue homeostasis and the resolution of inflammation. MerTK acts as a tolerogenic receptor in resting macrophages and during immunosuppression. It is expressed on tissue macrophages and belongs to the TAM family of tyrosine kinase receptors. Double expression of MerTK and CD64 (FcgR1) is becoming a defining criteria for macrophages, and helps in discriminating tissue macrophages from dendritic cells.
MerTK regulates macrophage activation, promotes apoptotic cell engulfment, and supports platelet aggregation and clot stability in vivo. MerTK is overexpressed or ectopically expressed in a wide variety of cancers, such as leukemia, non-small cell lung cancer, melanoma, prostate cancer, among others, potentially resulting in the activation of several canonical oncogenic signaling pathways.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents