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M-CSF

Alias: Macrophage Colony Stimulating Factor, Monocyte Colony Stimulating Factor, CSF-1, MCSF

M-CSF is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. M-CSF binds to the receptor tyrosine kinase c-Fms (CSF-1R or CD115) induces dimerization and autophosphorylation of the receptor followed by internalization and degradation of the complex. M-CSF is the primary cytokine for the mononuclear phagocyte lineage such as monocytes, macrophages, and osteoclasts. M-CSF regulates their development and effector functions. M-CSF also induces VEGF secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization.

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11 Item(s)

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Mouse Cytokine Panel 1B (10 plex)

Multiplex EPX100-26091 RUO

Human M-CSF Recombinant Carrier-Free

FA 34-8789 RUO

ProcartaPlex Mouse M-CSF Simplex

Multiplex EPX01A-26039 RUO

ProcartaPlex Human M-CSF Simplex

Multiplex EPX01A-12126 RUO

Human M-CSF Recombinant Protein

FA 14-8789 RUO

Mouse M-CSF Recombinant Protein

FA 14-8983 RUO

SAFE™ Human M-CSF Recombinant Animal Free Protein

FA 68-8783 RUO

Mouse M-CSF Recombinant Protein Carrier-Free

FA 34-8983 RUO

ProcartaPlex Mouse 36plex Control Set

Multiplex EPX360-26092* RUO

11 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents