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The Ly-49 family of NK-cell receptors, members of the C-type lectin superfamily, are disulfide-linked type-II transmembrane protein homodimers with extracellular carbohydrate-recognition domains which bind to MHC class I alloantigens. The Ly-49 family members are expressed independently, such that an individual NK or T cell may display more than one class of Ly-49 receptor homodimers. Ly-49D is expressed on subsets of natural killer cells in C57BL/6, C3H/He, and SJL mice, but not DBA/2, AKR, CBA/J, or BALB/c mice. The Ly-49D antigen has not been detected on NK-1.1+ T cells. The Ly-49D receptor has been implicated in mediation of NK cell cytolysis. Ly-49D is an activating receptor while Ly-49A is a inhibitory receptor.
A1; CH29-493D4.3; Chok; class I MHC receptor KLRA22; killer cell lectin-like receptor 4; killer cell lectin-like receptor subfamily A member 32; killer cell lectin-like receptor subfamily A member 33; killer cell lectin-like receptor, subfamily A, member 1; killer cell lectin-like receptor, subfamily A, member 4; Klra1; Klra22; Klra32; Klra33; Klra4; Ly49a; ly-49a; Ly49d; Ly-49d; Ly49-d; Ly49o<129>; ly49r<129>; Ly49v; lymphocyte antigen 49a; lymphocyte antigen 49d; natural killer cell receptor Ly49A; novel killer cell lectin-like receptor subfamily A protein; t lymphocyte antigen A1; T-cell surface glycoprotein Ly-49D; T-cell surface glycoprotein YE1/48
50 µg
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