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LIF

Alias: Leukemia Inhibitory Factor

LIF belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190 or LIFR, and the subunit gp130, which is shared with the other members of the IL-6 family. LIF expression has been observed in various tissues including thymus, lung, and neuronal tissue. LIF can be up-regulated by pro-inflammatory cytokines such as TNFα and IL-17, and elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis. LIF has been shown to inhibit the differentiation of TH17 cells in EAE mice and that of human TH17 cells derived from MS subjects. This is believed to occur through LIF exerting an opposing effect on the IL-6-induced STAT3 phosphorylation that is required for TH17 cell differentiation. LIF is most known in its ability to inhibit the differentiation of embryonic stem cells in mice and contribute to stem cell self-renewal. Inhibition of stem cell differentiation by LIF appears to be mouse-specific.

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20 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Mouse Cytokine Panel 1B (10 plex)

Multiplex EPX100-26091 RUO

ProcartaPlex Human Growth Factor Panel (11plex)

Multiplex EPX110-12170 RUO

Anti-human LIF

1F10 ELISA BMS1026* RUO

Anti-human LIF

7D2 ELISA, FA BMS1027* RUO

Human LIF Platinum ELISA

ELISA BMS242* RUO

Platinum ProcartaPlex Human LIF Simplex

Multiplex EPXP010-10242 RUO

ProcartaPlex Human LIF Simplex

Multiplex EPX01A-10242 RUO

ProcartaPlex Mouse LIF Simplex

Multiplex EPX01A-26040 RUO

Mouse LIF Recombinant Protein

FA 14-8521 RUO

Mouse LIF Recombinant Protein Carrier-Free

FA 34-8521 RUO

ProcartaPlex Mouse Myokine Panel (5 plex)

Multiplex EPX050-20833 RUO

ProcartaPlex Human Myokine Panel (8 plex)

Multiplex EPX080-12186 RUO

Platinum ProcartaPlex Human Panel 1 (42 plex)

Multiplex EPXP420-10200 RUO

Platinum ProcartaPlex Human 42plex Control Set

Multiplex EPXP420-10200* RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

ProcartaPlex Mouse 36plex Control Set

Multiplex EPX360-26092* RUO

20 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents