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IL-9

Alias: Interleukin-9, T-cell growth factor P40

IL-9 is a proinflammatory cytokine that was identified by its proliferative effects on T cell populations. IL-9 was historically believed to be involved in type 2 immune responses, however, recent evidence suggests IL-9 may be secreted by other T helper lineages such as TReg and TH17 in addition to a new category called TH9. This TH9 lineage can either be derived from TH2 cells with TGFβ or differentiated directly from naïve CD4+ T cells with TGFβ and IL-4. IL-9 is a member of the common cytokine receptor gamma chain-dependent family of cytokines that also includes IL-2, IL-4, IL-7, IL-15 and IL-21. IL-9 binds to a heterodimeric receptor composed of the γ chain portion (CD132) of the IL-2 receptor and the IL-9R chain. Once bound, it activates the JAK/STAT signaling pathways. Its pleiotropic effects on TH2 lymphocytes, B lymphocytes, mast cells, eosinophils, IgE production, and gut and airway epithelial cells have implicated IL-9 in asthma and other allergy-related disorders. The existence of an IL-9- mediated autocrine loop has been suggested for some malignancies such as Hodgkin’s disease and large cell anaplastic lymphoma for Hodgkin’s cell lines. IL-9 is expressed by Reed-Sternberg cells and Hodgkin lymphoma cells and some large aplastic lymphoma cells, while non-Hodgkin lymphomas and peripheral T-cell lymphomas do not express it.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1 (26 plex)

Multiplex EPXR260-26088 RUO

Human IL-9 Platinum ELISA

ELISA BMS2081* RUO

Human IL-9 ELISA Ready-SET-Go!®

ELISA 88-7958 RUO

Anti-Human IL-9 eFluor® 660

MH9A4 FC 50-7097 RUO

Anti-Human IL-9 eFluor® 450

MH9D1 FC 48-7098 RUO

Anti-Human IL-9 PE

MH9D1 FC 12-7098 RUO

Anti-Human IL-9 PE PerCP-eFluor® 710

MH9D1 FC 46-7098 RUO

Platinum ProcartaPlex Human IL-9 Simplex

Multiplex EPXP010-12081 RUO

ProcartaPlex Mouse IL-9 Simplex

Multiplex EPX01A-26041 RUO

ProcartaPlex Human IL-9 Simplex

Multiplex EPX01A-12081 RUO

Anti-Mouse IL-9 eFluor® 660

RM9A4 FC 50-8091 RUO

Mouse IL-9 ELISA Ready-SET-Go! (2nd Generation)

ELISA 88-8092 RUO

Mouse IL-9 Single-Use ELISA RSG Standard

ELISA 39-8952 RUO

Human IL-9 Single-Use ELISA RSG Standard

ELISA 39-8959 RUO

Anti-Mouse IL-9 Functional Grade Purified

D9302C12 FA 16-7093 RUO

Platinum ProcartaPlex Human Panel 1 (42 plex)

Multiplex EPXP420-10200 RUO

Platinum ProcartaPlex Human 42plex Control Set

Multiplex EPXP420-10200* RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents