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IL-8 (CXCL8)

Alias: Interleukin-8, CXCL8, NAP-1, MONAP, ANF, MDNCF, NAF

IL-8 is a member of the CXC chemokine family and is a major mediator of inflammatory response. IL-8 is induced by activators such as LPS, IL-1, and TNF to be produced/secrete from a variety of cell types that include monocytes, lymphocytes, granulocytes, fibroblasts, endothelial, and epithelial cells. IL-8 binds primarily to two GPCRs, CXCR1 and CXCR2, on neutrophils, monocytes, endothelial cells, astrocytes, and microglia. IL-8 functions as a strong chemoattractant and an angiogenic factor. Besides its chemotactic influence, IL-8 also triggers the secretion of superoxide anions and lysosomal enzymes in neutrophils. In basophils, IL-8 stimulates the histamine liberation. IL-8 selectively stimulates the ability of neutrophils and T-lymphocytes to invade injured or inflamed tissue. Other findings suggest that endothelial-derived IL-8 may function to attenuate inflammatory events at the interface between vessel wall and blood. IL-8 is also associated with a number diseases including rheumatoid arthritis, psoriasis, asthma, bladder cancer, blood incompatibility, contact dermatitis, graft rejection, inflammatory bowel disease, myocardial infarction, sepsis, and others.

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18 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Chemokine Panel 1 (9 plex)

Multiplex EPX090-12187 RUO

ProcartaPlex NHP Chemokine Panel (10 plex)

Multiplex EPX100-40041 RUO

ProcartaPlex Human Cytokine 1C & Chemokine Panel 1 (16 plex)

Multiplex EPX160-12176 RUO

ProcartaPlex Canine Cytokine/Chemokine/Growth Factor Panel 1 (11 plex)

Multiplex EPX11A-50511 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Essential Panel 2 (4 plex)

Multiplex EPX040-10008 RUO

Human IL-8 ELISA Ready-SET-Go!® (2nd Generation)

ELISA 88-8086 RUO

Anti-Human IL-8 (1-77) (CXCL8) Purified

N11 WB 14-7189 RUO

ProcartaPlex Porcine IL-8 (CXCL8) Simplex

Multiplex EPX01A-66052 RUO

ProcartaPlex NHP IL-8 (CXCL8) Simplex

Multiplex EPX01A-40204 RUO

ProcartaPlex Canine IL-8 (CXCL8) Simplex

Multiplex EPX01A-50506 RUO

ProcartaPlex Human Inflammation Panel (20 plex)

Multiplex EPX200-12185 RUO

ProcartaPlex Human Myokine Panel (8 plex)

Multiplex EPX080-12186 RUO

Platinum ProcartaPlex Human Panel 1 (42 plex)

Multiplex EPXP420-10200 RUO

Platinum ProcartaPlex Human Panel 2 (13 plex)

Multiplex EPXP130-10100 RUO

Platinum ProcartaPlex Human 42plex Control Set

Multiplex EPXP420-10200* RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

18 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents