IL-8 is a member of the CXC chemokine family and is a major mediator of inflammatory response. IL-8 is induced by activators such as LPS, IL-1, and TNF to be produced/secrete from a variety of cell types that include monocytes, lymphocytes, granulocytes, fibroblasts, endothelial, and epithelial cells. IL-8 binds primarily to two GPCRs, CXCR1 and CXCR2, on neutrophils, monocytes, endothelial cells, astrocytes, and microglia. IL-8 functions as a strong chemoattractant and an angiogenic factor. Besides its chemotactic influence, IL-8 also triggers the secretion of superoxide anions and lysosomal enzymes in neutrophils. In basophils, IL-8 stimulates the histamine liberation. IL-8 selectively stimulates the ability of neutrophils and T-lymphocytes to invade injured or inflamed tissue. Other findings suggest that endothelial-derived IL-8 may function to attenuate inflammatory events at the interface between vessel wall and blood. IL-8 is also associated with a number diseases including rheumatoid arthritis, psoriasis, asthma, bladder cancer, blood incompatibility, contact dermatitis, graft rejection, inflammatory bowel disease, myocardial infarction, sepsis, and others.
Unless indicated otherwise, all products are For Research Use Only. Not for use in diagnostic or therapeutic procedures. Not for further distribution without written consent. Not all products available in all regions.