IL-8
IL-8 is a member of the CXC chemokine family and is a major mediator of inflammatory response. IL-8 is induced by activators such as LPS, IL-1, and TNF to be produced/secrete from a variety of cell types that include monocytes, lymphocytes, granulocytes, fibroblasts, endothelial, and epithelial cells. IL-8 binds primarily to two GPCRs, CXCR1 and CXCR2, on neutrophils, monocytes, endothelial cells, astrocytes, and microglia. IL-8 functions as a strong chemoattractant and an angiogenic factor. Besides its chemotactic influence, IL-8 also triggers the secretion of superoxide anions and lysosomal enzymes in neutrophils. In basophils, IL-8 stimulates the histamine liberation. IL-8 selectively stimulates the ability of neutrophils and T-lymphocytes to invade injured or inflamed tissue. Other findings suggest that endothelial-derived IL-8 may function to attenuate inflammatory events at the interface between vessel wall and blood. IL-8 is also associated with a number diseases including rheumatoid arthritis, psoriasis, asthma, bladder cancer, blood incompatibility, contact dermatitis, graft rejection, inflammatory bowel disease, myocardial infarction, sepsis, and others.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents
