Alias: Interleukin-7, LP-1
IL-7 is an important cytokine that is required for human T cell development and for maintaining and restoring homeostasis of mature T cells. IL-7 is also involved in the proliferation of precursor B lymphocytes. IL-7 is produced mostly by non-hematopoietic stromal cells, rather than leukocytes such as T cells, B cells and NK cells. IL-7 signals through the heterodimeric IL-7 receptor composed of IL-7Rα (CD127) and the common γ chain (CD132) that is expressed by most resting T cells and is downregulated following T cell activation. IL-7 signaling through IL-7R activates the PI3K and JAK/STAT pathways to mediate anti-apoptotic and co-stimulatory proliferative signals. IL-7R activation also results in the downregulation of p27Kip1 and modulation of members of the Bcl-2 family. IL-7 is further responsible for the upregulation of the production of pro-inflammatory cytokines and the stimulation of the tumoricidal activity of monocytes/macrophages. Use of recombinant human IL-7 has be used in clinical trials for diseases such as melanoma, kidney cancer, HIV, HBV, HCV, stem cell transplantation, and pediatric solid tumors.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents