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IL-7

Alias: Interleukin-7, LP-1

IL-7 is an important cytokine that is required for human T cell development and for maintaining and restoring homeostasis of mature T cells. IL-7 is also involved in the proliferation of precursor B lymphocytes. IL-7 is produced mostly by non-hematopoietic stromal cells, rather than leukocytes such as T cells, B cells and NK cells. IL-7 signals through the heterodimeric IL-7 receptor composed of IL-7Rα (CD127) and the common γ chain (CD132) that is expressed by most resting T cells and is downregulated following T cell activation. IL-7 signaling through IL-7R activates the PI3K and JAK/STAT pathways to mediate anti-apoptotic and co-stimulatory proliferative signals. IL-7R activation also results in the downregulation of p27Kip1 and modulation of members of the Bcl-2 family. IL-7 is further responsible for the upregulation of the production of pro-inflammatory cytokines and the stimulation of the tumoricidal activity of monocytes/macrophages. Use of recombinant human IL-7 has be used in clinical trials for diseases such as melanoma, kidney cancer, HIV, HBV, HCV, stem cell transplantation, and pediatric solid tumors.

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23 Item(s)

Set Descending Direction
25 | 50
Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine 1C & Chemokine Panel 1 (16 plex)

Multiplex EPX160-12176 RUO

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Human Cytokine Panel 1C (7 plex)

Multiplex EPX070-10010 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex NHP Cytokine Panel 1b (6 plex)

Multiplex EPX060-40042 RUO

Platinum ProcartaPlex Human IL-7 Simplex

Multiplex EPXP010-10237 RUO

ProcartaPlex NHP IL-7 Simplex

Multiplex EPX01A-40237 RUO

ProcartaPlex Human IL-7 Simplex

Multiplex EPX01A-10237 RUO

ProcartaPlex Mouse IL-7 Simplex

Multiplex EPX01A-26094 RUO

Human IL-7 Recombinant Protein

FA 14-8079 RUO

Mouse IL-7 Recombinant Protein

FA 14-8071 RUO

Human IL-7 Recombinant Protein Carrier-Free

FA 34-8079 RUO

Mouse IL-7 Recombinant Protein Carrier-Free

FA 34-8071 RUO

Platinum ProcartaPlex Human Panel 1 (42 plex)

Multiplex EPXP420-10200 RUO

Platinum ProcartaPlex Human 42plex Control Set

Multiplex EPXP420-10200* RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

ProcartaPlex Human Th1/Th2 & Cytokine Panel 1C (18 plex)

Multiplex EPX180-12172 RUO

ProcartaPlex Human Th9/Th17/Th22/Treg & Cytokine Panel 1C (14 plex)

Multiplex EPX140-12174 RUO

23 Item(s)

Set Descending Direction
25 | 50

* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents