IL-6

Alias: Interleukin-6, B-cell hybridoma growth factor, Hybridoma growth factor

IL-6 pleiotropic TH2 cytokine produced by a variety of cell types that include monocytes, fibroblasts, and endothelial cells. Upon stimulation, IL-6 is secreted by many additional cell types including macrophages, T cells, B cells, mast cells, glial cells, eosinophils, keratinocytes, and granulocytes. IL-6 influences antigen-specific immune responses, inflammatory responses, it is a major mediator of the acute phase reaction and hematopoiesis, and plays a central role in host defense mechanisms. Furthermore, IL-6 is involved in B-cell differentiation, the induction of acute phase proteins in liver cells, growth promotion of myeloma/plasmacytoma/hybridoma cells, induction of IL-2 and IL-2R (CD25) expression, proliferation and differentiation of T cells, inhibition of cell growth of certain myeloid leukemic cell lines, and induction of their differentiation to macrophages. The level of IL-6 has proven to be a very important biomarker. This includes proliferative diseases where elevated plasma levels of IL-6 are observed in patients with multiple myeloma, other B-cell dyscrasias, Lennert’s T lymphoma, Castleman’s disease, renal cell carcinoma, and various other solid tumors. It is also an important biomarker in monitoring inflammatory responses were IL-6 is involved in the induction of acute phase proteins and induction of fever. Elevated serum levels of IL-6 are also found in patients with inflammatory arthritis and traumatic arthritis.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Porcine Cytokine & Chemokine Panel 1 (9 plex)

Multiplex EPX090-60829 RUO

ProcartaPlex Canine Cytokine/Chemokine/Growth Factor Panel 1 (11 plex)

Multiplex EPX110-50511 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Rat Cytokine & Chemokine Panel (22 plex)

Multiplex EPX220-30122 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

anti-mouse IL-6

6B4 IGH 54 ELISA, FA BMS178* RUO

anti-human IL-6/FITC

B-E8 FC, FA BMS130FI* RUO

Mouse IL-6 High Sensitivity ELISA

ELISA BMS603HS* RUO

Human IL-6 High Sensitivity ELISA

ELISA BMS213HS* RUO

Human IL-6 Instant ELISA

ELISA BMS213INST* RUO

Human IL-6 Instant ELISA

ELISA BMS213INSTCE* CE

Monkey IL-6 Instant ELISA

ELISA BMS641INST* RUO

Human IL-6 Matched Antibody Pairs

ELISA BMS213/2MST* RUO

Mouse IL-6 Platinum ELISA

ELISA BMS603/2* RUO

Human IL-6 Platinum ELISA

ELISA BMS213/2CE* CE

Monkey IL-6 Platinum ELISA

ELISA BMS641/2* RUO

Human IL-6 Platinum ELISA

ELISA BMS213/2* RUO

Rat IL-6 Platinum ELISA

ELISA BMS625* RUO

Mouse IL-6 ELISA Ready-SET-Go!®

ELISA 88-7064 RUO

Human IL-6 ELISA Ready-SET-Go!®

ELISA 88-7066 RUO

anti-human IL-6

I6YOR5/66 ELISA BMS130/2* RUO

Anti-Mouse IL-6 eFluor® 450

MP5-20F3 FC 48-7061 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT, Multiplexing Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; WB = Immunoprecipitation, Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents