Alias: Interleukin-5, B-cell differentiation factor I, T-cell replacing factor
IL-5 is a TH2 cytokine that acts as a hematopoietic growth factor that promotes proliferation, activation, and differentiation of eosinophils from bone marrow stem cells. In the human, IL-5 also supports generation of cytotoxic T cells, whereas in mice, IL-5 acts on B cells to induce IL-2R (CD25) expression on activated B cells, proliferation and secretion of IgM and IgA from endotoxin activated B cells.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents