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IL-4

Alias: Interleukin-4, B-cell stimulatory factor 1

IL-4 is a TH2 anti-inflammatory cytokine that is secreted by activated TH2 and NKT cells, and to a lesser extent by TH1 and mast cells. IL-4 exerts numerous effects on various hematopoietic cell types by biding to either type I or Type II IL-4R (the latter of which IL-13 also binds to and as such is also referred to as IL-13R). IL-4, by the means of STAT6 and GATA3, promotes TH2 cell differentiation that produces IL-4, IL-5, and IL-13. In B cells, IL-4 promotes proliferation and differentiation, promotes immunological class switching to IgE and IgG1 isotypes (in conjunction with other signals such as CD40), and upregulates MHC class II and CD23 expression. In T and B lymphocytes, mast cells, and endothelial cells, IL-4 promotes survival, growth, and differentiation. In macrophages, IL-4 can inhibit the production of TNF, IL-1, and IL-6. With its relevance to disease, IL-4 is an immune-stimulating molecule. As such it is one of the more recent targets being studied for new asthma treatments.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Porcine Cytokine & Chemokine Panel 1 (9 plex)

Multiplex EPX090-60829 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Rat Cytokine & Chemokine Panel (22 plex)

Multiplex EPX220-30122 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1 (26 plex)

Multiplex EPXR260-26088 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

ProcartaPlex Mouse High Sensitivity Panel (5 plex)

Multiplex EPXS050-22199 RUO

ProcartaPlex Human High Sensitivity Panel (9 plex)

Multiplex EPXS090-12199 RUO

Anti-Mouse IL-4 Alexa Fluor® 488

11B11 FC 53-7041 RUO

Anti-Mouse IL-4 APC

11B11 FC 17-7041 RUO

Anti-Mouse IL-4 Functional Grade Purified

11B11 ELISA, FA 16-7041 RUO

Anti-Mouse IL-4 PE

11B11 FC 12-7041 RUO

Anti-Mouse IL-4 PE-Cyanine7

11B11 FC 25-7041 RUO

Anti-Mouse IL-4 PerCP-eFluor® 710

11B11 FC 46-7041 RUO

Anti-Mouse IL-4 Purified

11B11 ELISA 14-7041 RUO

Anti-Human IL-4 Alexa Fluor® 488

8D4-8 FC 53-7049 RUO

Anti-Human IL-4 APC

8D4-8 FC 17-7049 RUO

Anti-Human IL-4 PE

8D4-8 FC 12-7049 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents