Alias: IFNλ, Interleukin-28A/B
IL-28A and IL-28B, along with IL-29 (also known as IFN-λ2, IFN-λ3, and IFN-λ1, respectively) are type III Interferons that belong to the IFNλ family; a novel family of cytokines within the IL-10 superfamily. IFNλ mediate their anti-viral protection through a class II cytokine receptor complex distinct from that of type I IFNs that is comprised of two essential receptor proteins, CRF2-12/IFN-λR1, which is unique to IFNλ, and CFR2-4/IL-10R2 that is shared with IL-10, IL-22, and IL-26 receptors. Whereas the two chains of the type I IFN receptor (IFN-AR1 and IFN-AR2) and IL-10R2 are ubiquitously expressed, IFNλR1 expression is limited and cell-type dependent. They signal through the JAK/STAT pathway in a similar manner as the type I IFNs (IFNα/β) and activates many of the same genes despite low sequence homology between the cytokines and receptors in the two families. Both IFN families display antiviral activity through the induction of antiviral protein production in target cells and the upregulation of MHC class I expression. These proteins also exhibit antiproliferative and antitumor effects, making them a possible alternative to IFNα cancer therapies. Unlike the type I IFNs, which are able to stimulate most cells, response to IFNλ stimulation appears to be limited to dendritic and some tumor cells due to the limited expression of IFNλR1.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents