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IL-27

IL-27 is a member of the IL-12 family of cytokines. IL-27 is a heterodimer composed of the Epstein-Barr virus induced gene 3 (EBI3) subunit and p28 (also known as IL-30). EBI3 is a 34-kDa glycoprotein is homologous to the p40 subunit of IL-12 and IL-23. The p28 subunit of IL-27 is similar to p35, and has been shown to function independently of EBI3. Studies demonstrate that IL-27 binds the receptor subunit WSX-1/TCCR (also known as IL-27Ra) that associates with gp130, a common chain utilized by IL-6 family cytokines. IL-27 binding to the IL-27R that is expressed most abundantly on activated T cells and NK cells with lower expression on B cells and naïve T-cells. This leads to the phosphorylation and activation of the JAK/STAT pathway, with STAT1 and STAT3 as the predominant factors mediating the effects of IL-27. In addition to its role in mediating pro- and anti-inflammatory effects, IL-27 promotes CD4+ T cell differentiation to the TH1 lineage by inducing expression of the transcription factor T-bet and up regulating IL-12Rβ2. In doing so, IL-27 suppresses TH2 and TH17 differentiation and proliferation. IL-27 is produced by activated dendritic cells and macrophages in response to Toll-like receptor ligands and pro-inflammatory cytokines.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1 (26 plex)

Multiplex EPXR260-26088 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

Human IL-27 Platinum ELISA

ELISA BMS2085* RUO

Mouse IL-27 Platinum ELISA

ELISA BMS6024* RUO

Human IL-27 ELISA Ready-SET-Go!®

ELISA 88-7278 RUO

Mouse IL-27 ELISA Ready-SET-Go!®

ELISA 88-7274 RUO

Mouse IL-27 Single-Use ELISA RSG Standard

ELISA 39-8271 RUO

ProcartaPlex Human IL-27 Simplex

Multiplex EPX01A-12085 RUO

Human IL-27 Recombinant Protein

FA 14-8279 RUO

Mouse IL-27 Recombinant Protein

FA 14-8271 RUO

Mouse IL-27 Recombinant Protein Carrier-Free

FA 34-8271 RUO

Anti-Mouse IL-27 p28 Functional Grade Purified

MM27-7B1 FA 16-7285 RUO

Anti-Mouse IL-27 p28 PE

MM27-7B1 FC 12-7285 RUO

Anti-Human IL-27 p28 eFluor® 660

3D1p28 FC 50-8277 RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

ProcartaPlex Mouse 36plex Control Set

Multiplex EPX360-26092* RUO

ProcartaPlex Mouse Th1/Th2/Th9/Th17/Th22/Treg Cytokine Panel (17 plex)

Multiplex EPX170-26087 RUO

ProcartaPlex Human Th1/Th2/Th9/Th17/Th22/Treg Cytokine Panel (18 plex)

Multiplex EPX180-12165 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents