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IL-23

IL-23 is a member of the IL-12 family of cytokines. IL-23 is secreted by activated dendritic cells and activated macrophages, and functions in innate and adaptive immunity to regulate TH17 function and proliferation. It is an important signal mediator of TH17 differentiation and is thought to contribute to the functional deviation of TH17 cells. Additionally, IL-23 induces CD8+ memory T cells to proliferate and produce IL-17. As such, IL-23 has been described as a key cytokine controlling inflammation in peripheral tissues. Structurally, IL-23 is a heterodimeric cytokine composed of the p40, shared with IL-12, and p19, a subunit that belongs to the IL-6 superfamily of cytokines. IL-23 interacts with a heterodimeric receptor composed of IL-12Rβ1 and IL-23R that binds to JAK/STATs. Despite activating similar signaling pathways to IL-12, IL-23 binding can lead to weaker activation, especially with STAT4. Expression of IL-23R is linked to the development of Crohn’s disease in humans.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1 (26 plex)

Multiplex EPXR260-26088 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

Anti-Human IL-23 p19 PE

23dcdp FC 12-7823 RUO

Anti-Mouse IL-23 p19 Purified

5B2 ELISA 14-7233 RUO

Anti-Human IL-23 p19 Purified

eBio473P19 ELISA, WB 14-7238 RUO

Human IL-23 Platinum ELISA

ELISA BMS2023/3* RUO

Mouse IL-23 Platinum ELISA

ELISA BMS6017* RUO

Human IL-23 ELISA Ready-SET-Go!® Set

ELISA 88-7237 RUO

Mouse IL-23 ELISA Ready-SET-Go!® (2nd Generation)

ELISA 88-7230 RUO

Anti-Mouse IL-23 p19 Purified

G23-8 ELISA, WB 14-7232 RUO

Anti-Human IL-23 p19 eFluor® 660

23dcdp FC 50-7823 RUO

Anti-Human IL-23 p19 PerCP-eFluor® 710

23dcdp FC 46-7823 RUO

Anti-Mouse IL-23 p19 Alexa Fluor® 488

fc23cpg FC 53-7023 RUO

Anti-Mouse IL-23 p19 eFluor® 660

fc23cpg FC 50-7023 RUO

Anti-Mouse IL-23 p19 PerCP-eFluor® 710

fc23cpg FC 46-7023 RUO

Anti-Mouse IL-23 p19 Functional Grade Purified

G23-8 ELISA, FA, WB 16-7232 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents