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IL-21

Alias: Interleukin-21

IL-21 is a memember of the type-I cytokine family and is an immunomodulatory cytokine produced mainly by NKT, TH17 and TFH cells. Structurally, IL-21 shows homology to IL-2, IL-4, and IL-15 proteins. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and JAK/STAT3, which leads to additional transcriptional activation by Bcl6. As with IFNγ for TH1 and IL-4 for TH2 cells, IL-21 is critical for TFH cell development and effector function. This cytokine plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells and stimulation of IgG production and induction of apoptotic signaling in naive B cells. In TH17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and RORγt lead to upregulation of the IL-23R, thereby preparing TH17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and RORγt, IL-21 also mediates the down-regulation of Foxp3. High levels of IL-21 are present in chemically induced colitis models. IL-21-deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate TH17-associated molecules.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

Anti-Human IL-21 Biotin

eBio2B2-G20 (2B2-G20) ELISA 13-7218 RUO

Anti-Human IL-21 eFluor® 660

eBio3A3-N2 (3A3-N2) FC 50-7219 RUO

Anti-Human IL-21 PE

eBio3A3-N2 (3A3-N2) FC 12-7219 RUO

Anti-Human IL-21 Purified

eBio3A3-N2 (3A3-N2) ELISA 14-7219 RUO

Human IL-21 Platinum ELISA

ELISA BMS2043* RUO

Mouse IL-21 ELISA Ready-SET-Go!®

ELISA 88-8210 RUO

Mouse IL-21 Single-Use ELISA RSG Standard

ELISA 39-8211 RUO

Mouse IL-21 ELISPOT Ready-SET-Go!®

ELISA 88-7210 RUO

Anti-Mouse IL-21 APC

FFA21 FC 17-7211 RUO

Anti-Mouse IL-21 eFluor® 660

FFA21 FC 50-7211 RUO

Anti-Mouse IL-21 Functional Grade Purified

FFA21 FA 16-7211 RUO

Anti-Mouse IL-21 PE

FFA21 FC 12-7211 RUO

Anti-Mouse IL-21 eFluor® 660

mhalx21 FC 50-7213 RUO

Anti-Mouse IL-21 PE

mhalx21 FC 12-7213 RUO

Mouse IL-21 Platinum ELISA

ELISA BMS6021* RUO

Platinum ProcartaPlex Human IL-21 Simplex

Multiplex EPXP010-12143 RUO

ProcartaPlex Mouse IL-21 Simplex

Multiplex EPX01A-26021 RUO

ProcartaPlex Human IL-21 Simplex

Multiplex EPX01A-12043 RUO

Human IL-21 Recombinant Protein

ELISA, FA 14-8219 RUO

Mouse IL-21 Recombinant Protein

ELISA, FA 14-8211 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents