IL-20 is a member of the IL-10 cytokine family that is expressed by monocytes, dendritic cells, and keratinocytes. IL-20 activates STAT3 by activating either of two heterodimeric receptor complexes. One of these consists of IL-20Rβ and IL-20Rα that can be activated by IL-19 and IL-24 as well as IL-20. The other, a complex of IL-20Rβ and IL-22Rα that is activated by only IL-20 and IL-24. IL-20 ligand binding induces the production of proinflammatory cytokines such as IL-1β, IL-6, and TNFα in monocytes and has been implicated in inflammatory conditions such as atherosclerosis, rheumatoid arthritis, and psoriasis. IL-20 also induces the proliferation of hematopoietic progenitor cells and keratinocytes.
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FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting
RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents