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IL-2

Alias: Interleukin-2

IL-2 is a TH1 cytokine that plays a central role in the activation and proliferation of lymphocytes that have been primed by antigens. IL-2 is pivotal for the expansion of most T cells, NK cells, and B cells during various phases of their response. IL-2 is made during T cell activation and fuels the growth of activated T cells. Apart from its most important role to mediate antigen-specific T lymphocyte proliferation, IL-2 also modulates the expression of IFNγ and MHC antigens, stimulates proliferation and differentiation of activated B cells, augments NK cell activity, and inhibits granulocyte-macrophage colony formation. IL-2 signals though various signaling pathways that include the activation of JAK/STAT5, the RAS/MAPK, and the PI3 Kinase pathways. These activations make IL-2 a known potent T cell growth factor, inducer of lymphokine-activated killer activity, boosts the cytolytic activity of NK cells, augmentation of Ig production, and an essential factor for the development of TReg cells. Even though IL-2 is a TH1 cytokine, it is a critical regulator of TH2 in a STAT5-dependent manner and an inhibitor TH17 differentiation/development. IL-2 is an important serum biomarker in several pathological situations such as cancer, infectious diseases, transplant rejection, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus and type I diabetes.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex Canine Cytokine/Chemokine/Growth Factor Panel 1 (11 plex)

Multiplex EPX11A-50511 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Rat Cytokine & Chemokine Panel (22 plex)

Multiplex EPX220-30122 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1 (26 plex)

Multiplex EPXR260-26088 RUO

ProcartaPlex Mouse High Sensitivity Panel (5 plex)

Multiplex EPXS050-22199 RUO

ProcartaPlex Human High Sensitivity Panel (9 plex)

Multiplex EPXS090-12199 RUO

Human IL-2 Recombinant Protein

FA 14-8029 RUO

Anti-Human IL-2 Functional Grade Purified

AB12-3G4 FA 16-7027 RUO

anti-human IL-2

B-G5 FA BMS128* RUO

Human IL-2 High Sensitivity ELISA

ELISA BMS221HS* RUO

Human IL-2 Instant ELISA

ELISA BMS221INST* RUO

Human IL-2 Instant ELISA

ELISA BMS221INSTCE* CE

Human IL-2 Lyophilized Standard

ELISA 29-8029 RUO

Mouse IL-2 Lyophilized Standard

ELISA 29-8021 RUO

Rat IL-2 Matched Antibody Pairs

ELISA BMS634MST* RUO

Human IL-2 Platinum ELISA

ELISA BMS221/2CE* CE

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents