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IL-18

Alias: Interleukin-18, IL1F4, IGIF

IL-18, an IL-1 family member, is a TH1-promoting cytokine. IL-18 is expressed by macrophages, dendritic cells, and ketatinocytes (epithelial cells). IL-18 binds to IL-18R on TH1 cells in response to IL-12 stimulation that results in the recruitment and its heterdimerization with IL-18RAP. This activates both the NFκB and MAPK pathways. The activity of IL-18 is held in control by IL-18BP, a soluble IL-18 binding protein found in 20-fold excess of IL-18 in non-inflammatory conditions. IL-18 is known to have various activities that include the induction of IL-4 and IL-13 basophils when combined with IL-3. IL-18 also works on dendritic cells to increase cytokine production and upregulation of MHC and co-stimulatory molecules. On macrophages, IL-18 enables the increased cytokine production and phagocytosis. In neutrophils, IL-18 helps to increase survival, adhesion, and oxidative burst and protease release. In basophils, IL-18 increases cytokine and histamine production. As a biomaker, high levels of IL-18 are found in both the blood and inflamed joints of rheumatoid arthritis patients.

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Name Clone Application Cat. No. Reg.  

ProcartaPlex Human Cytokine Panel 1B (25 plex)

Multiplex EPX250-12166 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1A (36 plex)

Multiplex EPX360-26092 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1A (36 plex)

Multiplex EPXR360-26092 RUO

ProcartaPlex Human Cytokine & Chemokine Convenience Panel 1A (34 plex)

Multiplex EPXR340-12167 RUO

ProcartaPlex Human Cytokine & Chemokine Panel 1A (34 plex)

Multiplex EPX340-12167 RUO

ProcartaPlex NHP Cytokine & Chemokine Panel (30 plex)

Multiplex EPX300-40044 RUO

ProcartaPlex NHP Cytokine/Chemokine/Growth Factor Panel (37 plex)

Multiplex EPX370-40045 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Convenience Panel 1 (45 plex)

Multiplex EPXR450-12171 RUO

ProcartaPlex Human Cytokine/Chemokine/Growth Factor Panel 1 (45 plex)

Multiplex EPX450-12171 RUO

ProcartaPlex Mouse Cytokine & Chemokine Convenience Panel 1 (26 plex)

Multiplex EPXR260-26088 RUO

ProcartaPlex Mouse Cytokine & Chemokine Panel 1 (26 plex)

Multiplex EPX260-26088 RUO

Pig IL-18 Platinum ELISA

ELISA BMS672* RUO

Anti-pig IL-18

7G8 ELISA, WB BMS1042* RUO

Human IL-18 Instant ELISA

ELISA BMS267INSTCE* CE

Human IL-18 Instant ELISA

ELISA BMS267INST* RUO

Human IL-18 Matched Antibody Pairs

ELISA BMS267/2MST* RUO

Human IL-18 Platinum ELISA

ELISA BMS267/2CE* CE

Mouse IL-18 Platinum ELISA

ELISA BMS618/3* RUO

Human IL-18 Platinum ELISA

ELISA BMS267/2* RUO

ProcartaPlex Mouse IL-18 Simplex

Multiplex EPX01A-20618 RUO

ProcartaPlex NHP IL-18 Simplex

Multiplex EPX01A-40267 RUO

ProcartaPlex Human IL-18 Simplex

Multiplex EPX01A-10267 RUO

ProcartaPlex Human 45plex Control Set

Multiplex EPX450-12171* RUO

ProcartaPlex Mouse 36plex Control Set

Multiplex EPX360-26092* RUO

ProcartaPlex NHP Th Panel (14 plex)

Multiplex EPX140-40040 RUO

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* = Please click on product link to see all available sizes and pricing.

FC = Flow Cytometry, Intracellular Staining/Flow Cytometry; ELISA = ELISA, ELISPOT; Multiplex = Multiplex Immunoassays; ICC = Immunocytochemistry; IHC = Immunohistochemistry, Immunofluorescence, Microscopy, Imaging, In Vivo Imaging; IHC-F = Immunohistochemical Staining of Frozen Tissue Sections; IHC-P = Immunohistochemical Staining of Formalin-Fixed Paraffin Embedded Tissue Sections; FA = Functional Assays, Bioassays, Neutralization, Depletion Studies, Biomolecule Conjugation; IP = Immunoprecipitation; WB = Western Blotting

RUO = Research Use Only; GPR = General Purpose Reagent; ASR = Analyte Specific Reagent. Analytical and performance characteristics are not established; CE = CE-marked reagents